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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Helicobacter


Psychiatry related information on Helicobacter


High impact information on Helicobacter

  • Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen [11].
  • A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization [12].
  • Helicobacter pylori interactions with host serum and extracellular matrix proteins: potential role in the infectious process [13].
  • Here we show that HpMutS2, a protein belonging to the MutS2 family in Helicobacter pylori, is not involved in mismatch repair but inhibits homologous and homeologous recombination [14].
  • Grb2 is a key mediator of helicobacter pylori CagA protein activities [15].

Chemical compound and disease context of Helicobacter


Biological context of Helicobacter


Anatomical context of Helicobacter


Gene context of Helicobacter


Analytical, diagnostic and therapeutic context of Helicobacter



  1. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. Hentschel, E., Brandstätter, G., Dragosics, B., Hirschl, A.M., Nemec, H., Schütze, K., Taufer, M., Wurzer, H. N. Engl. J. Med. (1993) [Pubmed]
  2. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. Kuipers, E.J., Lundell, L., Klinkenberg-Knol, E.C., Havu, N., Festen, H.P., Liedman, B., Lamers, C.B., Jansen, J.B., Dalenback, J., Snel, P., Nelis, G.F., Meuwissen, S.G. N. Engl. J. Med. (1996) [Pubmed]
  3. Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. You, W.C., Zhang, L., Gail, M.H., Chang, Y.S., Liu, W.D., Ma, J.L., Li, J.Y., Jin, M.L., Hu, Y.R., Yang, C.S., Blaser, M.J., Correa, P., Blot, W.J., Fraumeni, J.F., Xu, G.W. J. Natl. Cancer Inst. (2000) [Pubmed]
  4. Re: Helicobacter pylori and atrophic gastritis: importance of the cagA status. Rugge, M., Cassaro, M., Farinati, F., Saggioro, A., Di Mario, F. J. Natl. Cancer Inst. (1996) [Pubmed]
  5. Effect of transforming growth factor alpha and interleukin 8 on somatostatin release from canine fundic D cells. Beales, I., Calam, J., Post, L., Srinivasan, S., Yamada, T., DelValle, J. Gastroenterology (1997) [Pubmed]
  6. Multiple-dose safety and pharmacokinetics of oral garenoxacin in healthy subjects. Gajjar, D.A., Bello, A., Ge, Z., Christopher, L., Grasela, D.M. Antimicrob. Agents Chemother. (2003) [Pubmed]
  7. A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: The Hisayama study. Shikata, K., Kiyohara, Y., Kubo, M., Yonemoto, K., Ninomiya, T., Shirota, T., Tanizaki, Y., Doi, Y., Tanaka, K., Oishi, Y., Matsumoto, T., Iida, M. Int. J. Cancer (2006) [Pubmed]
  8. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Mendall, M.A., Patel, P., Asante, M., Ballam, L., Morris, J., Strachan, D.P., Camm, A.J., Northfield, T.C. Heart (1997) [Pubmed]
  9. A multicenter study on eradication of Helicobacter pylori infection in patients with duodenal ulcer by lansoprazole-antibiotics combined therapy. Yang, J.C., Yang, K.C., Hsu, C.T., Wang, C.S., Kuo, C.F., Wang, T.H. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. (1999) [Pubmed]
  10. Vitamin B12 status and its association with Helicobacter pylori infection in alcohol dependent patients. van Oijen, M.G., Laheij, R.J., de Jong, C.A., Peters, W.H., Jansen, J.B. J. Nutr. Sci. Vitaminol. (2004) [Pubmed]
  11. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. Chan, F.K., Chung, S.C., Suen, B.Y., Lee, Y.T., Leung, W.K., Leung, V.K., Wu, J.C., Lau, J.Y., Hui, Y., Lai, M.S., Chan, H.L., Sung, J.J. N. Engl. J. Med. (2001) [Pubmed]
  12. A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Weeks, D.L., Eskandari, S., Scott, D.R., Sachs, G. Science (2000) [Pubmed]
  13. Helicobacter pylori interactions with host serum and extracellular matrix proteins: potential role in the infectious process. Dubreuil, J.D., Giudice, G.D., Rappuoli, R. Microbiol. Mol. Biol. Rev. (2002) [Pubmed]
  14. Suppression of homologous and homeologous recombination by the bacterial MutS2 protein. Pinto, A.V., Mathieu, A., Marsin, S., Veaute, X., Ielpi, L., Labigne, A., Radicella, J.P. Mol. Cell (2005) [Pubmed]
  15. Grb2 is a key mediator of helicobacter pylori CagA protein activities. Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R., Sasakawa, C. Mol. Cell (2002) [Pubmed]
  16. Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN. Bergman, M.P., Engering, A., Smits, H.H., van Vliet, S.J., van Bodegraven, A.A., Wirth, H.P., Kapsenberg, M.L., Vandenbroucke-Grauls, C.M., van Kooyk, Y., Appelmelk, B.J. J. Exp. Med. (2004) [Pubmed]
  17. Clarithromycin and omeprazole for Helicobacter pylori. Logan, R.P., Gummett, P.A., Hegarty, B.T., Walker, M.M., Baron, J.H., Misiewicz, J.J. Lancet (1992) [Pubmed]
  18. Metronidazole-resistant Helicobacter pylori. Becx, M.C., Janssen, A.J., Clasener, H.A., de Koning, R.W. Lancet (1990) [Pubmed]
  19. Activity of lansoprazole against Helicobacter pylori. Megraud, F., Boyanova, L., Lamouliatte, H. Lancet (1991) [Pubmed]
  20. Helicobacter pylori resistance to tetracycline. Midolo, P.D., Korman, M.G., Turnidge, J.D., Lambert, J.R. Lancet (1996) [Pubmed]
  21. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. Rudi, J., Kuck, D., Strand, S., von Herbay, A., Mariani, S.M., Krammer, P.H., Galle, P.R., Stremmel, W. J. Clin. Invest. (1998) [Pubmed]
  22. Conservation of the cag pathogenicity island of Helicobacter pylori: associations with vacuolating cytotoxin allele and IS605 diversity. Slater, E., Owen, R.J., Williams, M., Pounder, R.E. Gastroenterology (1999) [Pubmed]
  23. Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers. Hamlet, A., Thoreson, A.C., Nilsson, O., Svennerholm, A.M., Olbe, L. Gastroenterology (1999) [Pubmed]
  24. Neutrophils, Helicobacter pylori, and nonsteroidal anti-inflammatory drug ulcers. Taha, A.S., Dahill, S., Morran, C., Hudson, N., Hawkey, C.J., Lee, F.D., Sturrock, R.D., Russell, R.I. Gastroenterology (1999) [Pubmed]
  25. Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism. Sagar, M., Tybring, G., Dahl, M.L., Bertilsson, L., Seensalu, R. Gastroenterology (2000) [Pubmed]
  26. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection. Ye, G., Barrera, C., Fan, X., Gourley, W.K., Crowe, S.E., Ernst, P.B., Reyes, V.E. J. Clin. Invest. (1997) [Pubmed]
  27. Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. Mai, U.E., Perez-Perez, G.I., Wahl, L.M., Wahl, S.M., Blaser, M.J., Smith, P.D. J. Clin. Invest. (1991) [Pubmed]
  28. Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer. Sidebotham, R.L., Baron, J.H. Lancet (1990) [Pubmed]
  29. Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Wirth, H.P., Yang, M., Peek, R.M., Tham, K.T., Blaser, M.J. Gastroenterology (1997) [Pubmed]
  30. Human gastrin: a Helicobacter pylori--specific growth factor. Chowers, M.Y., Keller, N., Tal, R., Barshack, I., Lang, R., Bar-Meir, S., Chowers, Y. Gastroenterology (1999) [Pubmed]
  31. Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection. Yamaoka, Y., Kudo, T., Lu, H., Casola, A., Brasier, A.R., Graham, D.Y. Gastroenterology (2004) [Pubmed]
  32. Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients. Byrd, J.C., Yan, P., Sternberg, L., Yunker, C.K., Scheiman, J.M., Bresalier, R.S. Gastroenterology (1997) [Pubmed]
  33. Inhibition of gastric mucin synthesis by Helicobacter pylori. Byrd, J.C., Yunker, C.K., Xu, Q.S., Sternberg, L.R., Bresalier, R.S. Gastroenterology (2000) [Pubmed]
  34. Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Fox, J.G., Li, X., Cahill, R.J., Andrutis, K., Rustgi, A.K., Odze, R., Wang, T.C. Gastroenterology (1996) [Pubmed]
  35. IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis. Queiroz, D.M., Guerra, J.B., Rocha, G.A., Rocha, A.M., Santos, A., De Oliveira, A.G., Cabral, M.M., Nogueira, A.M., De Oliveira, C.A. Gastroenterology (2004) [Pubmed]
  36. Proton-pump inhibitors or H2-receptor antagonists for Helicobacter pylori eradication-a meta-analysis. Holtmann, G., Layer, P., Goebell, H. Lancet (1996) [Pubmed]
  37. Chronic active gastritis due to Helicobacter pylori in immunized gnotobiotic piglets. Eaton, K.A., Krakowka, S. Gastroenterology (1992) [Pubmed]
  38. Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status. Gillen, D., Wirz, A.A., Ardill, J.E., McColl, K.E. Gastroenterology (1999) [Pubmed]
  39. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Maurer, K.J., Ihrig, M.M., Rogers, A.B., Ng, V., Bouchard, G., Leonard, M.R., Carey, M.C., Fox, J.G. Gastroenterology (2005) [Pubmed]
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