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Gene Review:

Ctcf - CCCTC-binding factor (zinc finger protein)

Rattus norvegicus

Synonyms: 11-zinc finger protein, CCCTC-binding factor, CTCFL paralog, Transcriptional repressor CTCF

Sheng, J. et al., Ding, Q. et al.

Sheng, Organ, Hao, Wells, Ruley, Rubin,

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High impact information on Ctcf

In particular, over-expression of 11-zinc finger protein and glypican may be responsible for the inhibition of axonal growth and regeneration [1].
In addition, Ctcf disruption and forced Igf2 expression both enabled cells to proliferate in soft agar, a phenotype associated with malignant growth in vivo [2].

Biological context of Ctcf

The disruption of Ctcf, which encodes a repressor of Igf2, was associated with enhanced Igf2 gene expression [2].

References

Proteome analysis of up-regulated proteins in the rat spinal cord induced by transection injury. Ding, Q., Wu, Z., Guo, Y., Zhao, C., Jia, Y., Kong, F., Chen, B., Wang, H., Xiong, S., Que, H., Jing, S., Liu, S. Proteomics (2006) [Pubmed]
Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection. Sheng, J., Organ, E.L., Hao, C., Wells, K.S., Ruley, H.E., Rubin, D.H. BMC Cell Biol. (2004) [Pubmed]

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