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Gene Review

PSD2  -  pleckstrin and Sec7 domain containing 2

Homo sapiens

Synonyms: DKFZp761B0514, EFA6C, PH and SEC7 domain-containing protein 2, Pleckstrin homology and SEC7 domain-containing protein 2
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High impact information on PSD2

  • Similar analyses of PtdSer transport to the locus of Psd2p now indicate that a membrane-bound phosphatidylinositol transfer protein and the C2 domain of Psd2p are both required on the acceptor membrane for efficient transport of PtdSer [1].
  • RESULTS: Considerably reduced amplitudes, prolonged durations and slowed conduction velocities are obtained for the intracellular potentials of the PSD2 and PSD3 cases [2].


  1. New perspectives on the regulation of intermembrane glycerophospholipid traffic. Voelker, D.R. J. Lipid Res. (2003) [Pubmed]
  2. Differences in potentials and excitability properties in simulated cases of demyelinating neuropathies. Part II. Paranodal demyelination. Stephanova, D.I., Daskalova, M. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2005) [Pubmed]
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