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Chemical Compound Review

DB00144     (2S)-2-amino-3-[[(2R)-2- butanoyloxy-3...

Synonyms: AC1O43S2, Phosphatidylserine, phosphatidyl-L-serine, LifeExtension PS Caps, O3-Phosphatidyl-L-serine, ...
 
 
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Disease relevance of Phosphatidylserine

 

Psychiatry related information on Phosphatidylserine

 

High impact information on Phosphatidylserine

 

Chemical compound and disease context of Phosphatidylserine

 

Biological context of Phosphatidylserine

 

Anatomical context of Phosphatidylserine

 

Associations of Phosphatidylserine with other chemical compounds

 

Gene context of Phosphatidylserine

  • ALA1 complements the deficiency in phosphatidylserine internalization into intact cells that is exhibited by the drs2 yeast mutant, and expression of ALA1 results in increased translocation of aminophospholipids in reconstituted yeast membrane vesicles [28].
  • However, cho1 yeast strains that are unable to synthesize PS do not phenocopy drs2 but instead transport proteins normally via the secretory pathway [29].
  • Therefore, whereas NBD-PS is a preferred substrate for Drs2p in vitro, endogenous PS is not an obligatory substrate in vivo for the role Drs2p plays in protein transport [29].
  • These data support a model for COAT-platelets where serotonin-derivatized procoagulant proteins interact with their respective receptors (eg, fibrinogen with glycoprotein IIb/IIIa or factor V with phosphatidylserine) as well as serotonin binding sites on fibrinogen and thrombospondin, resulting in a stable, multivalent complex on the cell surface [30].
  • Overexpression of cyclin E(276-395), but not of several other cyclin E mutants, specifically induced phosphatidylserine exposure and caspase activation in a dose-dependent manner, which were inhibited in Bcl-2-overexpressing cells or in the presence of zVAD-fmk [31].
 

Analytical, diagnostic and therapeutic context of Phosphatidylserine

References

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