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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

THOC3  -  THO complex 3

Homo sapiens

Synonyms: MGC5469, TEX1, TEX1 homolog, THO complex subunit 3, THO3, ...
 
 
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High impact information on THOC3

  • Treatment of FTC133A cells with the Golgi-perturbing agents monensin and brefeldin A led to a similar redistribution of immunoreactive species detected using both the Tex1 and anti-RD1 antisera [1].
  • Although the gene in G20 was 99% identical in DNA sequence to Tex1 in the 15.8 kb compared, gene disruption results indicate that it is only responsible for the production of an 18-mer peptaibol, and not 11-mer and 14-mer peptaibols [2].
  • This was based on analysis of their amino acid sequences which showed up to 86% identity to other PESs including TEX 1 [3].

References

  1. Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines. Pooley, L., Shakur, Y., Rena, G., Houslay, M.D. Biochem. J. (1997) [Pubmed]
  2. Multiple non-ribosomal peptide synthetase genes determine peptaibol synthesis in Trichoderma virens. Wei, X., Yang, F., Straney, D.C. Can. J. Microbiol. (2005) [Pubmed]
  3. Isolation and characterisation of a partial peptide synthetase gene from Trichoderma asperellum. Chutrakul, C., Peberdy, J.F. FEMS Microbiol. Lett. (2005) [Pubmed]
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