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Gene Review

USP45  -  ubiquitin specific peptidase 45

Homo sapiens

Synonyms: Deubiquitinating enzyme 45, MGC14793, Ubiquitin carboxyl-terminal hydrolase 45, Ubiquitin thioesterase 45, Ubiquitin-specific-processing protease 45
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Disease relevance of USP45

  • An efficient cell-surface display of E7mm was obtained in L. lactis using an expression cassette encoding a precursor composed of (i) the signal peptide and the first 15 amino acids of the mature part of the lactococcal Usp45 protein; (ii) E7mm and (iii) the cell-wall anchor of the Streptococcus pyogenes M6 protein (CWA(M6)) [1].


  1. Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli. Cortes-Perez, N.G., Azevedo, V., Alcocer-González, J.M., Rodriguez-Padilla, C., Tamez-Guerra, R.S., Corthier, G., Gruss, A., Langella, P., Bermúdez-Humarán, L.G. Journal of drug targeting. (2005) [Pubmed]
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