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Gene Review

SPB4  -  Spb4p

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent rRNA helicase SPB4, Suppressor of PAB1 protein 4, YFL002C
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High impact information on SPB4

  • Spb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae [1].
  • On sucrose gradients, HA-Spb4p was found almost exclusively in rapidly sedimenting complexes and showed a peak in the fractions containing the 66S pre-ribosomes [1].
  • Polysome analyses of strains genetically depleted of Spb4p or carrying the cold-sensitive spb4-1 mutation revealed an underaccumulation of 60S ribosomal subunits [1].


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