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Gene Review:

CDC26 - anaphase promoting complex subunit CDC26

Saccharomyces cerevisiae S288c

Synonyms: Anaphase-promoting complex subunit CDC26, Cell division control protein 26, HIT3, SCD26, YFR036W

Araki, H. et al., Dascher, C. et al., Hwang, L.H. et al., Kawakami, K. et al.

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High impact information on CDC26

We show that mutations in CDC26 and a novel gene, DOC1, also prevent mitotic cyclin proteolysis [1].
Nucleotide sequence of yeast SCD26, a dosage-dependent suppressor of the cell cycle mutation cdc26 [2].
The hit3-1 mutation was located on chromosome VI and affected the CDC26 gene [3].
Thus, the CDC26 gene is required for cell growth only at high temperature [4].
Nucleotide sequence analysis revealed that the gene we cloned was the same as SCD26, a dosage-dependent suppressor of cdc26 [4].

References

A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis. Hwang, L.H., Murray, A.W. Mol. Biol. Cell (1997) [Pubmed]
Nucleotide sequence of yeast SCD26, a dosage-dependent suppressor of the cell cycle mutation cdc26. Dascher, C., Küntzel, H. Nucleic Acids Res. (1989) [Pubmed]
Ty element-induced temperature-sensitive mutations of Saccharomyces cerevisiae. Kawakami, K., Shafer, B.K., Garfinkel, D.J., Strathern, J.N., Nakamura, Y. Genetics (1992) [Pubmed]
The CDC26 gene of Saccharomyces cerevisiae is required for cell growth only at high temperature. Araki, H., Awane, K., Ogawa, N., Oshima, Y. Mol. Gen. Genet. (1992) [Pubmed]

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