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Gene Review

INH1  -  Inh1p

Saccharomyces cerevisiae S288c

Synonyms: ATPase inhibitor, mitochondrial, D1305, YDL181W
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High impact information on INH1

  • Here we have directly addressed the involvement of the yeast inhibitor protein, Inh1, and its known accessory proteins, Stf1 and Stf2, in the formation of the yeast F1F0-ATP synthase dimer [1].
  • Furthermore, we demonstrate that the F1F0-ATPase monomers present in su e null mutant mitochondria can be as effectively inhibited by Inh1, as its dimeric counterpart in wild-type mitochondria [1].
  • We conclude that dimerization of the F1F0-ATP synthase complexes involves a physical interaction of the membrane-embedded F0 sectors from two monomeric complexes and in a manner that is independent of inhibitory activity of the Inh1 and accessory proteins [1].
  • In contrast, deletion of INH1, which encodes an inhibitor of the F(1)F(0)-ATPase, partially suppressed the growth defect of yme1 yeast lacking mitochondrial DNA [2].
  • Electrophoretic mapping of the STA and SGA genes is at present the only way to localize these genes, since glucoamylase repressor gene(s) (STA10, INH1 and/or IST2) are present in most laboratory strains of S. cerevisiae and the SGA phenotype is only detectable during sporulation [3].


  1. Formation of the yeast F1F0-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. Dienhart, M., Pfeiffer, K., Schagger, H., Stuart, R.A. J. Biol. Chem. (2002) [Pubmed]
  2. Genetic and biochemical basis for viability of yeast lacking mitochondrial genomes. Kominsky, D.J., Brownson, M.P., Updike, D.L., Thorsness, P.E. Genetics (2002) [Pubmed]
  3. Localization of yeast glucoamylase genes by PFGE and OFAGE. Pretorius, I.S., Marmur, J. Curr. Genet. (1988) [Pubmed]
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