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Gene Review:

PUS9 - pseudouridine synthase PUS9

Saccharomyces cerevisiae S288c

Synonyms: D2743, YDL036C, tRNA pseudouridine synthase 9, tRNA pseudouridine(32) synthase, mitochondrial, tRNA pseudouridylate synthase 9, ...

Behm-Ansmant, I. et al.

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High impact information on PUS9

By combining genetic and biochemical analyses, we demonstrate that two enzymes, Rib2/Pus8p and Pus9p, are required for Psi32 formation in cytoplasmic and mitochondrial tRNAs, respectively [1].

Anatomical context of PUS9

Pus9p acts mostly in mitochondria, and Rib2/Pus8p is strictly cytoplasmic [1].

References

Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae. Behm-Ansmant, I., Grosjean, H., Massenet, S., Motorin, Y., Branlant, C. J. Biol. Chem. (2004) [Pubmed]

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