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Gene Review:

DBP10 - Dbp10p

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent RNA helicase DBP10, D2770, DEAD box protein 10, YDL031W

Burger, F. et al., Bassler, J. et al.

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High impact information on DBP10

Nug1-N exhibits RNA binding activity and is genetically linked in an allele-specific way to the pre-60 S factors Noc2, Noc3, and Dbp10 [1].
Here we show that the previously uncharacterised open reading frame YDL031w (renamed DBP10 for DEAD-box protein 10) encodes an essential putative RNA helicase that is required for accurate ribosome biogenesis [2].
Consistent with a direct role in ribosome biogenesis, Dbp10p was found to be located predominantly in the nucleolus [2].
Genetic depletion of Dbp10p results in a deficit in 60S ribosomal subunits and an accumulation of half-mer polysomes [2].

References

The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles. Bassler, J., Kallas, M., Hurt, E. J. Biol. Chem. (2006) [Pubmed]
Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome biogenesis. Burger, F., Daugeron, M.C., Linder, P. Nucleic Acids Res. (2000) [Pubmed]

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