Disease relevance of Biogenesis

• SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome [1].
• Several investigations have indicated that mobility of membrane components, particularly lipopolysaccharide, is essential for biogenesis of the outer membrane, and is a primary event in phage infection [2].
• The effect of Vpu on class I biogenesis was analyzed in more detail using a Vpu-expressing recombinant vaccinia virus (VV) [3].
• An operon mediating biogenesis of digalactoside-binding pilus-adhesin of serotype F13 in uropathogenic Escherichia coli includes the regulatory gene papB [4].
• Bradyrhizobium japonicum TlpA, a novel membrane-anchored thioredoxin-like protein involved in the biogenesis of cytochrome aa3 and development of symbiosis [5].

Psychiatry related information on Biogenesis

• Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease [6].

High impact information on Biogenesis

• Ribonuclease P (RNase P) is an essential endonuclease that acts early in the tRNA biogenesis pathway [7].
• When both transcripts are present, a 24-nt siRNA is formed by a biogenesis pathway dependent on DCL2, RDR6, SGS3, and NRPD1A [8].
• Here we show that the small GTPase Sar1p directly initiates membrane curvature during vesicle biogenesis [9].
• Five alleles defective in synthesis of 21-nt, but not 24-nt, siRNAs carry mutations in Dicer-like 4 (DCL4) that are involved in biogenesis of trans-acting siRNAs [10].
• Human RISC couples microRNA biogenesis and posttranscriptional gene silencing [11].

Chemical compound and disease context of Biogenesis

• Previous studies showed that chronic lymphocytic leukemia (CLL) cells exhibit certain mitochondrial abnormalities including mtDNA mutations, increased superoxide generation, and aberrant mitochondrial biogenesis, which are associated with impaired apoptosis and reduced sensitivity to fludarabine [12].
• The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis [13].
• The alkane oxidation system of Pseudomonas oleovorans: induction of the alk genes in Escherichia coli W3110 (pGEc47) affects membrane biogenesis and results in overexpression of alkane hydroxylase in a distinct cytoplasmic membrane subfraction [14].
• Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis [15].
• Role of the carboxy-terminal phenylalanine in the biogenesis of outer membrane protein PhoE of Escherichia coli K-12 [16].

Biological context of Biogenesis

• These findings show that BLOC-1 is important in producing the HPS phenotype in humans, indicate that dysbindin has a role in the biogenesis of lysosome-related organelles and identify unexpected interactions between components of DPC and BLOC-1 [17].
• PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching [18].
• The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain [19].
• We show that the biogenesis and function of trans-acting siRNA can be genetically uncoupled from a bona fide DCL4-dependent pathway that accounts for RNA interference and for production of the 21-nt siRNA component of the plant cell-to-cell silencing signal [10].
• In vivo transcript abundance reflects codon usage and growth under stringent conditions for mitochondrial biogenesis and function results in a several fold higher level of gene expression than growth under glucose repression [20].

Anatomical context of Biogenesis

• Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders [21].
• The presence of consensus signal peptide sequences suggests that the product of the gene OPA1 is targeted to mitochondria and may exert its function in mitochondrial biogenesis and stabilization of mitochondrial membrane integrity [22].
• We conclude that CGA is an "on/off" switch that alone is sufficient to drive dense-core secretory granule biogenesis and hormone sequestration in endocrine cells [23].
• The mannose 6-phosphate receptor and the biogenesis of lysosomes [24].
• These results indicate that lateral membrane recruitment of the Sec6/8 complex is a consequence of cell-cell adhesion and is essential for the biogenesis of epithelial cell surface polarity [25].

Associations of Biogenesis with chemical compounds

• From glycogen to amylopectin: a model for the biogenesis of the plant starch granule [26].
• Biogenesis of the acetylcholine receptor, a multisubunit integral membrane protein [27].
• IRE1 is also required for inositol prototrophy, suggesting that the induction of ER resident proteins is coupled to the biogenesis of new ER membrane [28].
• Ligation of oligonucleotides by pyrimidine dimers--a missing 'link' in the origin of life [29]?
• Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets [30].

Gene context of Biogenesis

• These data demonstrate an important role for PEX1 in peroxisome biogenesis and suggest that mutations in this gene are the most common cause of the PBDs [31].
• These findings suggest a role for SMN and SIP1 in spliceosomal snRNP biogenesis and function and provide a likely molecular mechanism for the cause of SMA [32].
• Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders [33].
• Thus, the Nup84p complex in conjunction with Sec13-type proteins is required for correct nuclear pore biogenesis [34].
• 5. Thus, Tfam is the first mammalian protein demonstrated to regulate mtDNA copy number in vivo and is essential for mitochondrial biogenesis and embryonic development [35].

Analytical, diagnostic and therapeutic context of Biogenesis

• In total, 17 mutants having a general impairment of peroxisome biogenesis were isolated, as revealed by their inability to grow on oleic acid as the sole carbon source and their aberrant cell fractionation pattern of peroxisomal enzymes [36].
• Microinjection into macrophages of antibodies against EEA1 and the PI-3K hVPS34 reduced acquisition of late endocytic markers by latex bead phagosomes, demonstrating an essential role of these Rab5 effectors in phagosomal biogenesis [37].
• Chemical cross-linking and gel permeation chromatography were used to examine early events in the biogenesis of class I histocompatibility molecules [38].
• Immunofluorescence and immunogold analyses on normal human melanocytes confirmed the melanosomal membrane localization of the endogenous OA1 protein, consistent with its possible involvement in melanosome biogenesis [39].
• We examine a-factor biogenesis in a ste14 null mutant by metabolic labeling and immunoprecipitation and demonstrate that although proteolytic processing and membrane localization of a-factor are normal, the ste14 null mutant exhibits a profound block in a-factor export [40].

References