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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Biogenesis


Psychiatry related information on Biogenesis


High impact information on Biogenesis


Chemical compound and disease context of Biogenesis


Biological context of Biogenesis

  • These findings show that BLOC-1 is important in producing the HPS phenotype in humans, indicate that dysbindin has a role in the biogenesis of lysosome-related organelles and identify unexpected interactions between components of DPC and BLOC-1 [17].
  • PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching [18].
  • The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain [19].
  • We show that the biogenesis and function of trans-acting siRNA can be genetically uncoupled from a bona fide DCL4-dependent pathway that accounts for RNA interference and for production of the 21-nt siRNA component of the plant cell-to-cell silencing signal [10].
  • In vivo transcript abundance reflects codon usage and growth under stringent conditions for mitochondrial biogenesis and function results in a several fold higher level of gene expression than growth under glucose repression [20].

Anatomical context of Biogenesis


Associations of Biogenesis with chemical compounds


Gene context of Biogenesis


Analytical, diagnostic and therapeutic context of Biogenesis


  1. SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Zhu, Z., Yao, J., Johns, T., Fu, K., De Bie, I., Macmillan, C., Cuthbert, A.P., Newbold, R.F., Wang, J., Chevrette, M., Brown, G.K., Brown, R.M., Shoubridge, E.A. Nat. Genet. (1998) [Pubmed]
  2. Lateral diffusion of lipopolysaccharide in the outer membrane of Salmonella typhimurium. Schindler, M., Osborn, M.J., Koppel, D.E. Nature (1980) [Pubmed]
  3. The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I molecules. Kerkau, T., Bacik, I., Bennink, J.R., Yewdell, J.W., Húnig, T., Schimpl, A., Schubert, U. J. Exp. Med. (1997) [Pubmed]
  4. Autoregulation and multiple DNA interactions by a transcriptional regulatory protein in E. coli pili biogenesis. Forsman, K., Göransson, M., Uhlin, B.E. EMBO J. (1989) [Pubmed]
  5. Bradyrhizobium japonicum TlpA, a novel membrane-anchored thioredoxin-like protein involved in the biogenesis of cytochrome aa3 and development of symbiosis. Loferer, H., Bott, M., Hennecke, H. EMBO J. (1993) [Pubmed]
  6. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. Dyrks, T., Weidemann, A., Multhaup, G., Salbaum, J.M., Lemaire, H.G., Kang, J., Müller-Hill, B., Masters, C.L., Beyreuther, K. EMBO J. (1988) [Pubmed]
  7. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao, S., Scott, F., Fierke, C.A., Engelke, D.R. Annu. Rev. Biochem. (2002) [Pubmed]
  8. Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis. Borsani, O., Zhu, J., Verslues, P.E., Sunkar, R., Zhu, J.K. Cell (2005) [Pubmed]
  9. Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Lee, M.C., Orci, L., Hamamoto, S., Futai, E., Ravazzola, M., Schekman, R. Cell (2005) [Pubmed]
  10. DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal. Dunoyer, P., Himber, C., Voinnet, O. Nat. Genet. (2005) [Pubmed]
  11. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Gregory, R.I., Chendrimada, T.P., Cooch, N., Shiekhattar, R. Cell (2005) [Pubmed]
  12. Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL. Carew, J.S., Nawrocki, S.T., Krupnik, Y.V., Dunner, K., McConkey, D.J., Keating, M.J., Huang, P. Blood (2006) [Pubmed]
  13. The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. Domenech, P., Reed, M.B., Dowd, C.S., Manca, C., Kaplan, G., Barry, C.E. J. Biol. Chem. (2004) [Pubmed]
  14. The alkane oxidation system of Pseudomonas oleovorans: induction of the alk genes in Escherichia coli W3110 (pGEc47) affects membrane biogenesis and results in overexpression of alkane hydroxylase in a distinct cytoplasmic membrane subfraction. Nieboer, M., Kingma, J., Witholt, B. Mol. Microbiol. (1993) [Pubmed]
  15. Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis. Gehring, A.M., DeMoll, E., Fetherston, J.D., Mori, I., Mayhew, G.F., Blattner, F.R., Walsh, C.T., Perry, R.D. Chem. Biol. (1998) [Pubmed]
  16. Role of the carboxy-terminal phenylalanine in the biogenesis of outer membrane protein PhoE of Escherichia coli K-12. de Cock, H., Struyvé, M., Kleerebezem, M., van der Krift, T., Tommassen, J. J. Mol. Biol. (1997) [Pubmed]
  17. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Li, W., Zhang, Q., Oiso, N., Novak, E.K., Gautam, R., O'Brien, E.P., Tinsley, C.L., Blake, D.J., Spritz, R.A., Copeland, N.G., Jenkins, N.A., Amato, D., Roe, B.A., Starcevic, M., Dell'Angelica, E.C., Elliott, R.W., Mishra, V., Kingsmore, S.F., Paylor, R.E., Swank, R.T. Nat. Genet. (2003) [Pubmed]
  18. PGC-1alpha: turbocharging mitochondria. Houten, S.M., Auwerx, J. Cell (2004) [Pubmed]
  19. Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. Delprato, A., Merithew, E., Lambright, D.G. Cell (2004) [Pubmed]
  20. Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Masters, B.S., Stohl, L.L., Clayton, D.A. Cell (1987) [Pubmed]
  21. Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders. Portsteffen, H., Beyer, A., Becker, E., Epplen, C., Pawlak, A., Kunau, W.H., Dodt, G. Nat. Genet. (1997) [Pubmed]
  22. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Alexander, C., Votruba, M., Pesch, U.E., Thiselton, D.L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., Leo-Kottler, B., Auburger, G., Bhattacharya, S.S., Wissinger, B. Nat. Genet. (2000) [Pubmed]
  23. Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Kim, T., Tao-Cheng, J.H., Eiden, L.E., Loh, Y.P. Cell (2001) [Pubmed]
  24. The mannose 6-phosphate receptor and the biogenesis of lysosomes. Griffiths, G., Hoflack, B., Simons, K., Mellman, I., Kornfeld, S. Cell (1988) [Pubmed]
  25. Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Grindstaff, K.K., Yeaman, C., Anandasabapathy, N., Hsu, S.C., Rodriguez-Boulan, E., Scheller, R.H., Nelson, W.J. Cell (1998) [Pubmed]
  26. From glycogen to amylopectin: a model for the biogenesis of the plant starch granule. Ball, S., Guan, H.P., James, M., Myers, A., Keeling, P., Mouille, G., Buléon, A., Colonna, P., Preiss, J. Cell (1996) [Pubmed]
  27. Biogenesis of the acetylcholine receptor, a multisubunit integral membrane protein. Merlie, J.P. Cell (1984) [Pubmed]
  28. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cox, J.S., Shamu, C.E., Walter, P. Cell (1993) [Pubmed]
  29. Ligation of oligonucleotides by pyrimidine dimers--a missing 'link' in the origin of life? Lewis, R.J., Hanawalt, P.C. Nature (1982) [Pubmed]
  30. Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets. Turner, S.R., Tainer, J.A., Lynn, W.S. Nature (1975) [Pubmed]
  31. Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders. Reuber, B.E., Germain-Lee, E., Collins, C.S., Morrell, J.C., Ameritunga, R., Moser, H.W., Valle, D., Gould, S.J. Nat. Genet. (1997) [Pubmed]
  32. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Liu, Q., Fischer, U., Wang, F., Dreyfuss, G. Cell (1997) [Pubmed]
  33. Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Chang, C.C., Lee, W.H., Moser, H., Valle, D., Gould, S.J. Nat. Genet. (1997) [Pubmed]
  34. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Siniossoglou, S., Wimmer, C., Rieger, M., Doye, V., Tekotte, H., Weise, C., Emig, S., Segref, A., Hurt, E.C. Cell (1996) [Pubmed]
  35. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Larsson, N.G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G.S., Clayton, D.A. Nat. Genet. (1998) [Pubmed]
  36. Isolation of peroxisome assembly mutants from Saccharomyces cerevisiae with different morphologies using a novel positive selection procedure. Van der Leij, I., Van den Berg, M., Boot, R., Franse, M., Distel, B., Tabak, H.F. J. Cell Biol. (1992) [Pubmed]
  37. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. Fratti, R.A., Backer, J.M., Gruenberg, J., Corvera, S., Deretic, V. J. Cell Biol. (2001) [Pubmed]
  38. Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules. Degen, E., Williams, D.B. J. Cell Biol. (1991) [Pubmed]
  39. The ocular albinism type 1 gene product is a membrane glycoprotein localized to melanosomes. Schiaffino, M.V., Baschirotto, C., Pellegrini, G., Montalti, S., Tacchetti, C., De Luca, M., Ballabio, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  40. Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export. Sapperstein, S., Berkower, C., Michaelis, S. Mol. Cell. Biol. (1994) [Pubmed]
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