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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ESC2  -  Esc2p

Saccharomyces cerevisiae S288c

Synonyms: Establishes silent chromatin protein 2, Protein ESC2, YDR363W
 
 
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High impact information on ESC2

  • Molecular analysis suggested that Esc2p contributed to silencing in a manner similar to Sir1p and probably helped recruit or stabilize the other Sir proteins, while Htz1p present at HMR assembled a specialized chromatin structure necessary for silencing [1].
  • In a genetic screen for proteins that restore silencing when tethered to a telomere, we isolated ESC2 and an uncharacterized gene, (YOL017w), which we call ESC8 [2].

References

  1. A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Dhillon, N., Kamakaka, R.T. Mol. Cell (2000) [Pubmed]
  2. Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8. Cuperus, G., Shore, D. Genetics (2002) [Pubmed]
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