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Gene Review

POA1  -  Poa1p

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribose 1''-phosphate phosphatase, YBR022W, YBR0304
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High impact information on POA1

  • We used a biochemical genomics approach to identify two yeast phosphatases that can convert Appr1p to ADP-ribose: the product of ORF YBR022w (now Poa1p), which is completely unrelated to other known phosphatases; and Hal2p, a known 3'-phosphatase of 5',3'-pAp [1].

Associations of POA1 with chemical compounds

  • Furthermore, Poa1p is strongly inhibited by ADP-ribose (K(I), 17 microM), modestly inhibited by other nucleotides containing an ADP-ribose moiety and not inhibited at all by other tested molecules [1].


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