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Gene Review

Prkcdbp  -  protein kinase C, delta binding protein

Rattus norvegicus

Synonyms: Cavin-3, D3T-inducible gene 2 protein, DIG-2, Dig2, Dithiolethione-inducible gene 2 protein, ...
 
 
 
 
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High impact information on Prkcdbp

  • Clones representing genes not previously associated with detoxification were isolated, including those for ferritin heavy and light subunits, ribosomal proteins L18a and S16 and two novel genes, termed dithiolethione-inducible genes (or DIG-1 and DIG-2) [1].
 

Biological context of Prkcdbp

  • The transcriptional activation of ferritin, ribosomal protein, DIG-1 and DIG-2 genes in conjunction with those of carcinogen detoxification enzymes suggests that they participate in the pleiotropic cellular defense response to dithiolethiones that inhibits chemically produced tumorigenesis [1].

References

  1. Isolation of cDNAs representing dithiolethione-responsive genes. Primiano, T., Gastel, J.A., Kensler, T.W., Sutter, T.R. Carcinogenesis (1996) [Pubmed]
 
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