The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Prkcdbp  -  protein kinase C, delta binding protein

Mus musculus

Synonyms: 3110015B12Rik, 6330514M23Rik, Cavin-3, Protein kinase C delta-binding protein, SRBC, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Prkcdbp


Psychiatry related information on Prkcdbp

  • The greatest depression of the response to SRBC was associated with an interval of 14 days between infection and the administration of antigen, suggesting that a particular stage of the parasite contributed significantly to immunodepression during this critical period [6].

High impact information on Prkcdbp

  • Both passive transfer of cutaneous DTH to SRBC and passive transfer of the largely monocytic T cell-dependent recruitment to tuberculin in the peritoneal cavity were completely abolished by systemic 5C6 treatment [1].
  • First, mice were depleted of C3 by treatment with cobra venom factor (CVF) and then immunized with SRBC with or without IgM-anti-SRBC [7].
  • We have developed a plasma-free system in which washed mouse platelets lyse washed antibody and complement-sensitized SRBC targets in the presence of EDTA [8].
  • These findings, as well as the fact that platelets do not lyse unsensitized innocent bystander SRBC, suggest that the complete cytotoxic system of platelets capable of specific recognition and lysis resides in their membranes [8].
  • Examination of antibody responses to SRBC revealed that approximately half the normal number of indirect PFCs were observed [9].

Chemical compound and disease context of Prkcdbp


Biological context of Prkcdbp

  • Isolated cells were cultured for 48 h in the presence of a variety of TNP conjugates including TNP-Brucella abortus (Ba), TNP-Ficoll, TNP-sheep erythrocytes (SRBC), TNP-human gamma globulin (HGG), or TNP-ovalbumin (OVA) before being harvested and subjected to acridine orange cell cycle analysis [15].
  • Inhibiting apoptosis by in vivo cyclosporine treatment prolonged lung lymphocyte accumulation following SRBC challenge [5].
  • FcgammaR-mediated phagocytosis of IgG-coated SRBC was also significantly decreased in Rac2-null macrophages, as was NADPH oxidase activity in response to phorbol ester or FcgammaR stimulation [16].
  • Human LDL-In is not species specific and was capable of suppressing the in vivo mouse anti-sheep erythrocyte (SRBC) hemagglutination response by 88% after the administration of 500 to 600 mug LDL-In IV, whereas human serum high density lipoproteins and fibrinogen had no effect [17].
  • T helper cells from these mice, immunized to SRBC, were restricted to cooperation with B cells of the thymic H-2 haplotype [18].

Anatomical context of Prkcdbp

  • Development of two distinct types of suppressor T cells was revealed in the spleen of mice after the priming with SRBC [19].
  • Cultures of purified sIgA+ B cells, cloned PP Th A cells and SRBC, selectively yielded IgA antibody producers [20].
  • Most of these analogue-reactive PFC preferentially lyse analogue-conjugated SRBC and cannot be detected on erythrocytes bearing the immunizing hapten [21].
  • 19S helper cells in nonimmune animals were nonrosette-forming small lymphocytes; after immunization with SRBC in complete Freund's adjuvant, 19S helper cells were nonrosette-forming medium lymphocytes [22].
  • In pretreated recipients, the transfer of activated B cells, but not of T cells or macrophages, resulted in an augmented production of indirect plaque-forming cells in the primary immune response to SRBC but not to horse erythrocytes [23].

Associations of Prkcdbp with chemical compounds

  • Daily gastric intubation of lipopolysaccharide (LPS)-responsive C3H/HeN, BALB/c, and Swiss mice with SRBC for 2 wk resulted in oral tolerance, whereas similarly treated LPS-nonresponsive C3H/HeJ mice gave splenic anti-SRBC PFC responses, including the IgA isotype, after systemic challenge with antigen [24].
  • To evaluate the mechanisms of this suppression, the in vitro antibody response to SRBC was studied using cells from cytoxan-treated mice [25].
  • N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) stimulates in vitro primary immune responses to SRBC in T cell-depleted (nude) spleen cultures [26].
  • Additional studies revealed that prior injection of BCG influencdd the ensuing magnitude of SRBC-induced trapping [27].
  • Mice were immunized by i.v. injection of SRBC or by topical application of picryl chloride, and the responses were elicited by cutaneous challenge with the appropriate Ag [28].

Analytical, diagnostic and therapeutic context of Prkcdbp

  • Spleen cell cultures from xid mice were unresponsive to SRBC and TI-2 antigens [29].
  • C3H/HeJ mice given SRBC orally for 4 wk are not rendered tolerant to this antigen and were used as a source of PP Tcs cells for adoptive transfer to identically treated, orally tolerized C3H/HeN mice [30].
  • No SRBC binding by helper cells was observed under the conditions of rosette formation used [22].
  • The plaque assay, utilizing SRBC to which Staphylococcal protein A had been coupled, the developing anti-supernatant antiserum and guinea pig complement, readily detected secreting T cells [31].
  • Intravenous injection of 5C6, a CR3-specific rat mAb known to impair myelomonocytic adhesion, divided the DTH to SRBC in actively immunized mice into two phases [1].


  1. Antibody to the murine type 3 complement receptor inhibits T lymphocyte-dependent recruitment of myelomonocytic cells in vivo. Rosen, H., Milon, G., Gordon, S. J. Exp. Med. (1989) [Pubmed]
  2. The adjuvant effect of Corynebacterium parvum: T-cell dependence of macrophage activation. Sljivić, V.S., Watson, S.R. J. Exp. Med. (1977) [Pubmed]
  3. Phosphatidyl choline is recognized by a series of Ly-1+ murine B cell lymphomas specific for erythrocyte membranes. Mercolino, T.J., Arnold, L.W., Haughton, G. J. Exp. Med. (1986) [Pubmed]
  4. B cell dependence on and response to accessory signals in murine lupus strains. Prud'homme, G.J., Balderas, R.S., Dixon, F.J., Theofilopoulos, A.N. J. Exp. Med. (1983) [Pubmed]
  5. Lung lymphocyte elimination by apoptosis in the murine response to intratracheal particulate antigen. Milik, A.M., Buechner-Maxwell, V.A., Sonstein, J., Kim, S., Seitzman, G.D., Beals, T.F., Curtis, J.L. J. Clin. Invest. (1997) [Pubmed]
  6. Nematospiroides dubius: factors affecting the primary response to SRBC in infected mice. Ali, N.M., Behnke, J.M. J. Helminthol. (1983) [Pubmed]
  7. Complement activation is required for IgM-mediated enhancement of the antibody response. Heyman, B., Pilström, L., Shulman, M.J. J. Exp. Med. (1988) [Pubmed]
  8. Platelet-mediated cytotoxicity. Role of antibody and C3, and localization of the cytotoxic system in membranes. Slezak, S., Symer, D.E., Shin, H.S. J. Exp. Med. (1987) [Pubmed]
  9. Development of multiple organ-localized autoimmune diseases in nude mice after reconstitution of T cell function by rat fetal thymus graft. Taguchi, O., Takahashi, T., Seto, M., Namikawa, R., Matsuyama, M., Nishizuka, Y. J. Exp. Med. (1986) [Pubmed]
  10. Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions. Girolomoni, G., Tigelaar, R.E. J. Immunol. (1990) [Pubmed]
  11. Antigen induced alterations in splenic prostaglandin and cyclic nucleotide levels in NZB mice. Webb, D.R., Nowowiejski, I., Dauphinée, M., Talal, N. J. Immunol. (1977) [Pubmed]
  12. Relationships among differentiated T-cell subpopulations. I. Dissociated development of tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper function. Ohmichi, Y., Nomoto, K., Yamada, H., Takeya, K. Immunology (1976) [Pubmed]
  13. Effects of suramin on the immune responses to sheep red blood cells in mice. II. In vitro studies. Motta, I., Brandely, M., Truffa-Bachi, P., Hurtrel, B., Lagrange, P. Cell. Immunol. (1985) [Pubmed]
  14. Higher ADCC of murine peritoneal cells after immunization with allogenic tumor cells as compared with stimulation by adriamycin, BCG, and thioglycolate. Haisma, H.J., Ligtenberg, M., Dullens, H.F., Den Otter, W. Cell. Immunol. (1986) [Pubmed]
  15. Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells. Cambier, J.C., Monroe, J.G., Neale, M.J. J. Exp. Med. (1982) [Pubmed]
  16. Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. Yamauchi, A., Kim, C., Li, S., Marchal, C.C., Towe, J., Atkinson, S.J., Dinauer, M.C. J. Immunol. (2004) [Pubmed]
  17. In vivo suppression of the primary immune response by a species of low density serum lipoprotein. Curtiss, L.K., DeHeer, D.H., Edgington, T.S. J. Immunol. (1977) [Pubmed]
  18. Genetic control of the immune response to collagen. III. Coordinate restriction of cellular cooperation and antigen responsiveness by thymus-directed maturation. Hedrick, S.M., Watson, J. J. Immunol. (1980) [Pubmed]
  19. Virus-replicating T cells in the immune response of mice. III. Role of vesicular stomatitis virus-replicating T cells in the antibody response. Minato, N., Katsura, Y. J. Exp. Med. (1978) [Pubmed]
  20. Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses. Kiyono, H., Cooper, M.D., Kearney, J.F., Mosteller, L.M., Michalek, S.M., Koopman, W.J., McGhee, J.R. J. Exp. Med. (1984) [Pubmed]
  21. Hapten-specific hemolytic plaque assays usually fail to detect most of the diversity in the anti-hapten response. Merchant, B., Inman, J.K. J. Exp. Med. (1977) [Pubmed]
  22. Rosette-forming ability of thymus-derived lymphocytes in humoral and cell-mediated immunity. II. Helper cell activity. Elliott, B.E., Haskill, J.S. J. Exp. Med. (1975) [Pubmed]
  23. Priming of T helper cells by antigen-activated B cells. B cell-primed Lyt-1+ helper cells are restricted to cooperate with B cells expressing the IgvH phenotype of the priming B cells. L'Age-Stehr, J. J. Exp. Med. (1981) [Pubmed]
  24. Lack of oral tolerance in C3H/HeJ mice. Kiyono, H., McGhee, J.R., Wannemuehler, M.J., Michalek, S.M. J. Exp. Med. (1982) [Pubmed]
  25. SAA suppression of immune response in vitro: evidence for an effect on T cell-macrophage interaction. Aldo-Benson, M.A., Benson, M.D. J. Immunol. (1982) [Pubmed]
  26. Effect of a synthetic adjuvant on the induction of primary immune responses in T cell-depleted spleen cultures. Watson, J., Whitlock, C. J. Immunol. (1978) [Pubmed]
  27. Effects of BCG on lymphocyte trapping. Zatz, M.M. J. Immunol. (1976) [Pubmed]
  28. Transforming growth factor-beta 1 inhibits murine immediate and delayed type hypersensitivity. Meade, R., Askenase, P.W., Geba, G.P., Neddermann, K., Jacoby, R.O., Pasternak, R.D. J. Immunol. (1992) [Pubmed]
  29. Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice. Eldridge, J.H., Kiyono, H., Michalek, S.M., McGhee, J.R. J. Exp. Med. (1983) [Pubmed]
  30. Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer's patches. Suzuki, I., Kitamura, K., Kiyono, H., Kurita, T., Green, D.R., McGhee, J.R. J. Exp. Med. (1986) [Pubmed]
  31. A hemolytic plaque assay for activated murine T cells. Primi, D., Lewis, G.K., Goodman, J.W. J. Exp. Med. (1979) [Pubmed]
WikiGenes - Universities