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Gene Review:

EXO70 - Exo70p

Saccharomyces cerevisiae S288c

Synonyms: Exocyst complex component EXO70, Exocyst complex protein of 70 kDa, J0932, YJL085W

Roumanie, O. et al., Robinson, N.G. et al., Matern, H.T. et al., He, B. et al.

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High impact information on EXO70

Our analysis of a Rho3 mutant that is unable to interact with the Exo70 subunit of the exocyst reveals a normal polarization of the exocyst complex as well as other polarity markers [1].
Cells overexpressing GFP-Exo70 fail to form a tight monolayer, suggesting the Exo70 targeting interaction is critical for normal development of polarized epithelial cells [2].
Two proteins, Exo70 and Myo2, were identified in this screen [3].

Associations of EXO70 with chemical compounds

We found that the C-terminal Domain D of Exo70 directly interacts with phosphatidylinositol 4,5-bisphosphate [4].

Other interactions of EXO70

Overlapping subcellular localization of the Rho3 and Exo70 proteins was demonstrated by indirect immunofluorescence [3].

References

Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex. Roumanie, O., Wu, H., Molk, J.N., Rossi, G., Bloom, K., Brennwald, P. J. Cell Biol. (2005) [Pubmed]
The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Matern, H.T., Yeaman, C., Nelson, W.J., Scheller, R.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70. Robinson, N.G., Guo, L., Imai, J., Toh-E, A., Matsui, Y., Tamanoi, F. Mol. Cell. Biol. (1999) [Pubmed]
Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. He, B., Xi, F., Zhang, X., Zhang, J., Guo, W. EMBO J. (2007) [Pubmed]

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AGOS_AFR100W	Ashbya gossypii ATCC 10895
KLLA0F14421g	Kluyveromyces lactis NRRL Y-1140
MGG_01760	Magnaporthe oryzae 70-15
NCU08012	Neurospora crassa OR74A

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