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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BUD2  -  Bud2p

Saccharomyces cerevisiae S288c

Synonyms: Bud site selection protein 2, CLA2, ERC25, Inhibitory regulator protein BUD2/CLA2, YKL092C, ...
 
 
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High impact information on BUD2

  • We have identified a gene, BUD5, that resembles BUD1 and BUD2 in being required for both patterns; bud5- mutants also exhibit random budding in all cell types [1].
  • Like Bud5, Bud2 associates with the axial division remnant, but rather than being inherited, Bud2 transiently associates with the remnant in late G1, before condensing into a patch at the incipient bud site [2].
  • The three remaining ORFs have no identity to known proteins within the databases screened and are not assigned ORF numbers as they are completely contained with ORFs YKL424 and YKL425 [3].
 

Regulatory relationships of BUD2

  • The relative timing of Bud5 and Bud2 localizations suggests that both regulators contribute to the spatially specific control of Bud1 GTPase [2].
 

Other interactions of BUD2

References

  1. Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1. Chant, J., Corrado, K., Pringle, J.R., Herskowitz, I. Cell (1991) [Pubmed]
  2. A localized GTPase exchange factor, Bud5, determines the orientation of division axes in yeast. Marston, A.L., Chen, T., Yang, M.C., Belhumeur, P., Chant, J. Curr. Biol. (2001) [Pubmed]
  3. Sequence analysis of a 3.5 Kb EcoRI fragment from the left arm of Saccharomyces cerevisiae chromosome XI reveals the location of the MBR1 gene and a sequence related to a GTPase-activating protein. James, C.M., Gent, M.E., Oliver, S.G. Yeast (1994) [Pubmed]
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