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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PXL1  -  Pxl1p

Saccharomyces cerevisiae S288c

Synonyms: Paxillin-like protein 1, YKR090W
 
 
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High impact information on PXL1

  • However, Pxl1p directly binds to Rho1p-GDP in vitro, and inhibits the growth of rho1-2 and rho1-3 mutants in a dosage-dependent manner [1].
  • Genetic analyses of strains lacking both PXL1 and the Rho GAP BEM2 demonstrate that such cells display pronounced growth defects in response to different conditions causing Rho1 pathway activation [2].
  • We found that YKR090w functions in a manner analogous to paxillin as a mediator of polarized cell growth; thus, we have named this gene PXL1 (Paxillin-like protein 1) [2].
  • Deletion of PXL1 does not produce any obvious phenotype [1].

References

  1. Pxl1p, a paxillin-like protein in Saccharomyces cerevisiae, may coordinate Cdc42p and Rho1p functions during polarized growth. Gao, X.D., Caviston, J.P., Tcheperegine, S.E., Bi, E. Mol. Biol. Cell (2004) [Pubmed]
  2. The PXL1 gene of Saccharomyces cerevisiae encodes a paxillin-like protein functioning in polarized cell growth. Mackin, N.A., Sousou, T.J., Erdman, S.E. Mol. Biol. Cell (2004) [Pubmed]
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