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Gene Review

FRE7  -  Fre7p

Saccharomyces cerevisiae S288c

Synonyms: AOB629, Ferric-chelate reductase 7, Ferric/cupric reductase transmembrane component 7, YOL152W
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High impact information on FRE7

  • Spacing between Mac1-responsive sites is important as shown by the attenuated expression of FRE7 and CTR1 when two elements are separated by over 100 base pairs [1].
  • Two elements are critical for Mac1-dependent FRE7 expression [1].
  • From the three Mac1-responsive elements in FRE7, a new consensus sequence for Mac1 binding can be established as TTTGC(T/G)C(A/G) [1].


  1. Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. Martins, L.J., Jensen, L.T., Simon, J.R., Keller, G.L., Winge, D.R., Simons, J.R. J. Biol. Chem. (1998) [Pubmed]
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