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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ALG8  -  dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP...

Saccharomyces cerevisiae S288c

Synonyms: Asparagine-linked glycosylation protein 8, Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase, YOR067C, ...
 
 
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High impact information on ALG8

  • This new synthetic phenotype made it possible to isolate the ALG8 locus, encoding a potential glucosyltransferase of the endoplasmic reticulum [1].
  • Alg6p has sequence similarity to Alg8p, a protein required for glucosylation of Glc1Man9GlcNAc2 [2].
  • As compared with alg5 and alg6, alg8 secreted a higher proportion of ExgII, which was paralleled by a significant drop in the proportion of ExgTuni and, to a lesser extent, of ExgII1/2 [3].
 

Biological context of ALG8

  • New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus [1].

References

  1. New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus. Stagljar, I., te Heesen, S., Aebi, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway. Reiss, G., te Heesen, S., Zimmerman, J., Robbins, P.W., Aebi, M. Glycobiology (1996) [Pubmed]
  3. Glycosylation of yeast exoglucanase sequons in alg mutants deficient in the glucosylation steps of the lipid-linked oligosaccharide. Presence of glucotriose unit in Dol-PP-GlcNAc2Man9Glc3 influences both glycosylation efficiency and selection of N-linked sites. Muñoz, M.D., Hernández, L.M., Basco, R., Andaluz, E., Larriba, G. Biochim. Biophys. Acta (1994) [Pubmed]
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