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Gene Review

ALG6  -  dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol...

Saccharomyces cerevisiae S288c

Synonyms: Asparagine-linked glycosylation protein 6, Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase, UNA544, ...
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High impact information on ALG6

  • Microsomal membranes from a mutant strain that synthesized glucosylphosphodolichol but lacked the ability to transfer the glucosyl residue to the growing lipid-linked oligosaccharide (alg6) exhibited labeling with 5-azido[beta-32P]UDPGlc comparable to that found in microsomes from the wild-type strain [1].
  • These aberrant protein-linked oligosaccharides were processed by the addition of outer chain residues in the alg3, alg5, and alg6 mutants [2].
  • Monoglucosylated protein-linked oligosaccharides were detected in alg6 or alg5 mutant cells, which transfer Man9GlcNAc2 to protein; glucosylation was dependent on the inhibition of glucosidase II or the disruption of the gene encoding this enzyme [3].
  • Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway [4].
  • Alg6p has sequence similarity to Alg8p, a protein required for glucosylation of Glc1Man9GlcNAc2 [4].

Other interactions of ALG6

  • These mutants synthesize and transfer to nascent proteins truncated oligosaccharides lacking two (alg8) or three (alg5 and alg6) glucoses [5].


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