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Gene Review

YVC1  -  Yvc1p

Saccharomyces cerevisiae S288c

Synonyms: Calcium channel YVC1, TRP homolog, YOR087W, YOR088W, YOR3151W, ...
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High impact information on YVC1

  • Here we report that Yvc1p, a vacuolar membrane protein with homology to transient receptor potential (TRP) channels, mediates the hyperosmolarity induced Ca(2+) release [1].
  • It appears that, on upshock, a transient osmotic force activates Yvc1p to release Ca2+ from the vacuole [2].
  • By using a combination of gene deletion and re-expression with direct patch clamping of the yeast vacuolar membrane, we show that this yeast TRP-like gene is necessary for the YVC1 conductance [3].

Anatomical context of YVC1


  1. Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue. Denis, V., Cyert, M.S. J. Cell Biol. (2002) [Pubmed]
  2. The transient receptor potential channel on the yeast vacuole is mechanosensitive. Zhou, X.L., Batiza, A.F., Loukin, S.H., Palmer, C.P., Kung, C., Saimi, Y. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane. Palmer, C.P., Zhou, X.L., Lin, J., Loukin, S.H., Kung, C., Saimi, Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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