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Gene Review

NFI1  -  SUMO ligase NFI1

Saccharomyces cerevisiae S288c

Synonyms: E3 SUMO-protein ligase SIZ2, SAP and Miz-finger domain-containing protein 2, SIZ2, YOR156C
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High impact information on NFI1

  • However, yeast mutants lacking the SUMO ligases Siz1 and Siz2/Nfi1 are viable, even though they show dramatically reduced levels of SUMO conjugation [1].
  • Nfi1/Siz2 stimulated Smt3 conjugation to Cdc3 in vitro [2].

Other interactions of NFI1

  • Using this polysumoylation-deficient mutant Smt3, we found that Cdc3 and Nfi1/Siz2 were modified with Smt3 at multiple sites [2].


  1. Misregulation of 2 microm circle copy number in a SUMO pathway mutant. Chen, X.L., Reindle, A., Johnson, E.S. Mol. Cell. Biol. (2005) [Pubmed]
  2. Comparative analysis of yeast PIAS-type SUMO ligases in vivo and in vitro. Takahashi, Y., Toh-E, A., Kikuchi, Y. J. Biochem. (2003) [Pubmed]
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