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Gene Review

RUD3  -  Rud3p

Saccharomyces cerevisiae S288c

Synonyms: GRIP domain-containing protein RUD3, GRP1, Golgin-related protein 1, Relieves USO1-1 transport defect protein 3, YOR216C, ...
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High impact information on RUD3

  • In contrast, Rud3p binds to the GTPase Arf1p via this COOH-terminal "GRIP-related Arf-binding" (GRAB) domain [1].
  • We find that Rud3p is localized to the Golgi via a COOH-terminal domain that is distantly related to the GRIP domain that recruits several coiled-coil proteins to the trans-Golgi by binding the small Arf-like GTPase Arl1p [1].
  • Deletion of RUD3 is lethal in the absence of the Golgi GTPase Ypt6p, and a screen of other mutants showing a similar genetic interaction revealed that Golgi targeting of Rud3p also requires Erv14p, a cargo receptor that cycles between the endoplasmic reticulum and Golgi [1].
  • Finally, we describe RUD3, a novel gene identified through a genetic screen for multicopy suppressors of a mutation in USO1, which suppresses the sec34-2 mutation as well [2].


  1. The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi. Gillingham, A.K., Tong, A.H., Boone, C., Munro, S. J. Cell Biol. (2004) [Pubmed]
  2. Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p. VanRheenen, S.M., Cao, X., Sapperstein, S.K., Chiang, E.C., Lupashin, V.V., Barlowe, C., Waters, M.G. J. Cell Biol. (1999) [Pubmed]
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