High impact information on ERV14

• The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi [1].
• Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product [2].
• One of these polypeptides, termed Erv14p (ER-vesicle protein of 14 kD), corresponds to an open reading frame on yeast chromosome VII that is predicted to encode an integral membrane protein and shares sequence identity with the Drosophila cornichon gene product [2].
• Drosophila Cornichon (Cni) is the founding member of a conserved protein family that also includes Erv14p, an integral component of the COPII-coated vesicles that mediate cargo export from the yeast endoplasmic reticulum (ER) [3].
• Erv14p directs a transmembrane secretory protein into COPII-coated transport vesicles [4].

Biological context of ERV14

• Haploid cells that lack Erv14p are viable but display a modest defect in bud site selection because a transmembrane secretory protein, Axl2p, is not efficiently delivered to the cell surface [2].

Anatomical context of ERV14

• Deletion of ERV14 causes a defect in polarized growth because Axl2p, a transmembrane secretory protein, accumulates in the endoplasmic reticulum and is not delivered to its site of function on the cell surface [4].

Regulatory relationships of ERV14

• Overexpression of the ERV14 paralog ERV15 largely suppressed the sporulation defect in erv14 cells [5].

Other interactions of ERV14

• Interestingly, the inviability of strains bearing several mutant alleles of DSL1 can be suppressed by expression of either Erv14p (a protein required for the movement of a specific protein from the ER to the Golgi), Sec21p (the gamma-subunit of the COPI coat protein complex coatomer), or Sly1-20p [6].

References