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Gene Review

ERV14  -  Erv14p

Saccharomyces cerevisiae S288c

Synonyms: ER-derived vesicles protein ERV14, YGL054C
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High impact information on ERV14


Biological context of ERV14

  • Haploid cells that lack Erv14p are viable but display a modest defect in bud site selection because a transmembrane secretory protein, Axl2p, is not efficiently delivered to the cell surface [2].

Anatomical context of ERV14

  • Deletion of ERV14 causes a defect in polarized growth because Axl2p, a transmembrane secretory protein, accumulates in the endoplasmic reticulum and is not delivered to its site of function on the cell surface [4].

Regulatory relationships of ERV14

  • Overexpression of the ERV14 paralog ERV15 largely suppressed the sporulation defect in erv14 cells [5].

Other interactions of ERV14

  • Interestingly, the inviability of strains bearing several mutant alleles of DSL1 can be suppressed by expression of either Erv14p (a protein required for the movement of a specific protein from the ER to the Golgi), Sec21p (the gamma-subunit of the COPI coat protein complex coatomer), or Sly1-20p [6].


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