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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RRP5  -  Rrp5p

Saccharomyces cerevisiae S288c

Synonyms: FMI1, Ribosomal RNA-processing protein 5, U3 small nucleolar RNA-associated protein RRP5, U3 snoRNA-associated protein RRP5, YM9959.11C, ...
 
 
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High impact information on RRP5

  • A screen for mutations showing synthetic lethality with deletion of the non-essential snoRNA, snR10, identified a novel gene, RRP5, which is essential for viability and encodes a 193 kDa nucleolar protein [1].
  • Interestingly, the ROK1 gene which, like RRP5, was previously isolated in a screen for synthetic lethal mutations with snR10 deletion, was here identified as a high copy suppressor of the rrp5delta6 temperature-sensitive allele [2].
  • Deletion derivatives of snR10 were constructed and tested for the ability to suppress the sg and ts phenotypes of the RRP5 mutant, as well as for complementation of the cold sensitivity of a delta snr10 strain [3].

References

  1. RRP5 is required for formation of both 18S and 5.8S rRNA in yeast. Venema, J., Tollervey, D. EMBO J. (1996) [Pubmed]
  2. Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae. Torchet, C., Jacq, C., Hermann-Le Denmat, S. RNA (1998) [Pubmed]
  3. High dosage of the small nucleolar RNA snR10 specifically suppresses defects of a yeast rrp5 mutant. Torchet, C., Hermann-Le Denmat, S. Mol. Genet. Genomics (2002) [Pubmed]
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