Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CUS1 - Cus1p

Saccharomyces cerevisiae S288c

Synonyms: Cold sensitive U2 snRNA suppressor 1, YM9408.02C, YMR240C

Pauling, M.H. et al., Wang, Q. et al., Igel, H. et al.

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High impact information on CUS1

Here proteomic and genetic studies identify Rcp10p as p10 and show that it contributes to SF3b stability and is necessary for normal cellular Cus1p accumulation and for U2 snRNP recruitment in splicing [1].
Biochemical fractionation of splicing extracts and reconstitution of heat-inactivated splicing extracts from strains carrying a temperature-sensitive allele of CUS1 indicate that Cus1p and Hsh155p reside in a functional, high-salt-stable complex that is salt-dissociable from U2 snRNA [2].
Using bacterially expressed proteins, we find that yeast HSH49 binds CUS1 [3].

Other interactions of CUS1

In vivo interaction tests show that HSH49 and CUS1 associate primarily through the N-terminal RRM of HSH49 [3].

References

Interactions of the yeast SF3b splicing factor. Wang, Q., He, J., Lynn, B., Rymond, B.C. Mol. Cell. Biol. (2005) [Pubmed]
Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Pauling, M.H., McPheeters, D.S., Ares, M. Mol. Cell. Biol. (2000) [Pubmed]
Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits. Igel, H., Wells, S., Perriman, R., Ares, M. RNA (1998) [Pubmed]

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