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Gene Review: 

YSF3  -  Ysf3p

Saccharomyces cerevisiae S288c

Synonyms: RCP10, RDS3 complex subunit 10, Splicing factor 3b subunit, YNL138W-A
 
 
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High impact information on YSF3

  • Here proteomic and genetic studies identify Rcp10p as p10 and show that it contributes to SF3b stability and is necessary for normal cellular Cus1p accumulation and for U2 snRNP recruitment in splicing [1].
  • Remarkably, only the final 53 amino acids of Rcp10p are essential. p17 is shown to be composed of two accessory splicing factors, Bud31p and Ist3p, the latter of which independently associates with the RES complex implicated in the nuclear pre-mRNA retention [1].
  • Consistent with its role in RNA splicing, yeast 2-hybrid and glutathione S-transferase pull-down assays show that RBM7 interacts with splicing factor 3b subunit 2 (SAP145), and with the splicing regulator, SRp20 [2].

References

  1. Interactions of the yeast SF3b splicing factor. Wang, Q., He, J., Lynn, B., Rymond, B.C. Mol. Cell. Biol. (2005) [Pubmed]
  2. Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. Guo, T.B., Boros, L.G., Chan, K.C., Hikim, A.P., Hudson, A.P., Swerdloff, R.S., Mitchell, A.P., Salameh, W.A. J. Androl. (2003) [Pubmed]
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