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Gene Review: 

POP1  -  Pop1p

Saccharomyces cerevisiae S288c

Synonyms: N1285, RNA-processing protein POP1, RNases P/MRP 100.4 kDa subunit, Ribonucleases P/MRP protein subunit POP1, YNL221C
 
 
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High impact information on POP1

  • The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins [1].
  • Only two protein subunits, Pop1p and Pop4p, specifically bind the RNA subunit [2].
  • Cig2 phosphorylation is also required for interaction with Pop1 [3].
  • Further ongoing studies of this enzyme reveal an extensive network of interactions between subunits and a probable central role for the Pop1, Pop4 and Pop7 subunits [4].
 

Analytical, diagnostic and therapeutic context of POP1

 

 

References

  1. The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins. Lygerou, Z., Mitchell, P., Petfalski, E., Séraphin, B., Tollervey, D. Genes Dev. (1994) [Pubmed]
  2. Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. Houser-Scott, F., Xiao, S., Millikin, C.E., Zengel, J.M., Lindahl, L., Engelke, D.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2. Yamano, H., Kominami, K., Harrison, C., Kitamura, K., Katayama, S., Dhut, S., Hunt, T., Toda, T. J. Biol. Chem. (2004) [Pubmed]
  4. Probing the structure of Saccharomyces cerevisiae RNase MRP. Walker, S.C., Aspinall, T.V., Gordon, J.M., Avis, J.M. Biochem. Soc. Trans. (2005) [Pubmed]
  5. Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP. Xiao, S., Hsieh, J., Nugent, R.L., Coughlin, D.J., Fierke, C.A., Engelke, D.R. RNA (2006) [Pubmed]
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