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Gene Review

RIA1  -  GTPase RIA1

Saccharomyces cerevisiae S288c

Synonyms: EF-2-like GTPase, EFL1, Elongation factor-like 1, N1718, Ribosome assembly protein 1, ...
 
 
 
 
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High impact information on RIA1

  • The dominant TIF6 alleles can also suppress the phenotype associated with a complete deletion of the RIA1 gene [1].
  • Localization experiments with HA-tagged derivatives of Ria1p did not detect any stable association of Ria1p with ribosome subunits, 80S monosomes or polysomes [1].
  • Dissociation of the monosomes and polysomes in the Ria1p depletion mutant revealed a specific reduction in the amount of 60S subunits [1].
  • Taken together, these data suggest that Ria1p is involved in the biogenesis of the 60S subunit of the ribosome [1].
 

Biological context of RIA1

  • In the case of a 22-residue C-terminal deletion this can be suppressed by intragenic mutations in the RIA1 gene or dominant extragenic mutations in TIF6, which is thought to be involved in the biogenesis of the 60S subunit of the ribosome [1].
 

Analytical, diagnostic and therapeutic context of RIA1

References

 
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