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Gene Review

LSM7  -  Sm-like protein LSM7

Saccharomyces cerevisiae S288c

Synonyms: N1202, N1780, U6 snRNA-associated Sm-like protein LSm7, YNL147W
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High impact information on LSM7

  • Here we show that mutations in seven yeast Lsm proteins (Lsm1-Lsm7) also lead to inhibition of mRNA decapping [1].
  • Coprecipitation experiments demonstrated that Lsm1p, together with Lsm2p-Lsm7p, forms a new seven-subunit complex [2].
  • This polysome association was further verified by using a conditional allele of essential translation initiation factor PRT1, which markedly decreased polysome association of viral genomic RNA in the presence or absence of an LSM7 mutation [3].

Other interactions of LSM7

  • First, mutations in the LSM1 to LSM7, as well as PAT1, genes led to the accumulation of MFA2pG and PGK1pG transcripts that had been shortened by 10-20 nucleotides at their 3' ends (referred to as trimming) [4].


  1. Yeast Sm-like proteins function in mRNA decapping and decay. Tharun, S., He, W., Mayes, A.E., Lennertz, P., Beggs, J.D., Parker, R. Nature (2000) [Pubmed]
  2. A Sm-like protein complex that participates in mRNA degradation. Bouveret, E., Rigaut, G., Shevchenko, A., Wilm, M., Séraphin, B. EMBO J. (2000) [Pubmed]
  3. Yeast Lsm1p-7p/Pat1p deadenylation-dependent mRNA-decapping factors are required for brome mosaic virus genomic RNA translation. Noueiry, A.O., Diez, J., Falk, S.P., Chen, J., Ahlquist, P. Mol. Cell. Biol. (2003) [Pubmed]
  4. The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation. He, W., Parker, R. Genetics (2001) [Pubmed]
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