The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

LSM7  -  Sm-like protein LSM7

Saccharomyces cerevisiae S288c

Synonyms: N1202, N1780, U6 snRNA-associated Sm-like protein LSm7, YNL147W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on LSM7

  • Here we show that mutations in seven yeast Lsm proteins (Lsm1-Lsm7) also lead to inhibition of mRNA decapping [1].
  • Coprecipitation experiments demonstrated that Lsm1p, together with Lsm2p-Lsm7p, forms a new seven-subunit complex [2].
  • This polysome association was further verified by using a conditional allele of essential translation initiation factor PRT1, which markedly decreased polysome association of viral genomic RNA in the presence or absence of an LSM7 mutation [3].
 

Other interactions of LSM7

  • First, mutations in the LSM1 to LSM7, as well as PAT1, genes led to the accumulation of MFA2pG and PGK1pG transcripts that had been shortened by 10-20 nucleotides at their 3' ends (referred to as trimming) [4].

References

  1. Yeast Sm-like proteins function in mRNA decapping and decay. Tharun, S., He, W., Mayes, A.E., Lennertz, P., Beggs, J.D., Parker, R. Nature (2000) [Pubmed]
  2. A Sm-like protein complex that participates in mRNA degradation. Bouveret, E., Rigaut, G., Shevchenko, A., Wilm, M., Séraphin, B. EMBO J. (2000) [Pubmed]
  3. Yeast Lsm1p-7p/Pat1p deadenylation-dependent mRNA-decapping factors are required for brome mosaic virus genomic RNA translation. Noueiry, A.O., Diez, J., Falk, S.P., Chen, J., Ahlquist, P. Mol. Cell. Biol. (2003) [Pubmed]
  4. The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation. He, W., Parker, R. Genetics (2001) [Pubmed]
 
WikiGenes - Universities