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Gene Review

LSM2  -  Sm-like protein LSM2

Saccharomyces cerevisiae S288c

Synonyms: SMX5, SNP3, Small nuclear ribonucleoprotein D homolog SNP3, U6 snRNA-associated Sm-like protein LSm2, YBL026W, ...
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High impact information on LSM2

  • Coprecipitation experiments demonstrated that Lsm1p, together with Lsm2p-Lsm7p, forms a new seven-subunit complex [1].
  • This confirmed the association of the Lsm2p-Lsm8p complex with U6 snRNA [1].
  • LSM2 and LSM4, but not other LSM genes, act as allele-specific, low-copy suppressors of mutations in Lsm8p [2].

Other interactions of LSM2

  • A complex of seven Sm-like proteins, Lsm2-Lsm8, also binds the 3' end of U6 snRNA [2].


  1. A Sm-like protein complex that participates in mRNA degradation. Bouveret, E., Rigaut, G., Shevchenko, A., Wilm, M., Séraphin, B. EMBO J. (2000) [Pubmed]
  2. Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein. Pannone, B.K., Kim, S.D., Noe, D.A., Wolin, S.L. Genetics (2001) [Pubmed]
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