The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

ZRG17  -  Zn(2+) transporter ZRG17

Saccharomyces cerevisiae S288c

Synonyms: N3403, Protein ZRG17, YNR039C, Zinc-regulated gene 17 protein
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on ZRG17

  • In our model, Yke4p balances zinc levels between the cytosol and the secretory pathway, whereas the previously described Msc2p-Zrg17p ER zinc importer complex functions mainly in zinc-depleted conditions to ensure a ready supply of zinc essential for ER functions, such as phospholipid biosynthesis and unfolded protein response [1].
  • ZRG17 was previously identified as a zinc-regulated gene controlled by the zinc-responsive Zap1p transcription factor [2].
  • A zrg17 mutant exhibits the same zinc-suppressible phenotypes as an msc2 mutant, including an induction of the unfolded protein response in low zinc [2].
 

Analytical, diagnostic and therapeutic context of ZRG17

References

  1. YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. Kumánovics, A., Poruk, K.E., Osborn, K.A., Ward, D.M., Kaplan, J. J. Biol. Chem. (2006) [Pubmed]
  2. Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells. Ellis, C.D., Macdiarmid, C.W., Eide, D.J. J. Biol. Chem. (2005) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities