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Gene Review

ZRG17  -  Zn(2+) transporter ZRG17

Saccharomyces cerevisiae S288c

Synonyms: N3403, Protein ZRG17, YNR039C, Zinc-regulated gene 17 protein
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High impact information on ZRG17

  • In our model, Yke4p balances zinc levels between the cytosol and the secretory pathway, whereas the previously described Msc2p-Zrg17p ER zinc importer complex functions mainly in zinc-depleted conditions to ensure a ready supply of zinc essential for ER functions, such as phospholipid biosynthesis and unfolded protein response [1].
  • ZRG17 was previously identified as a zinc-regulated gene controlled by the zinc-responsive Zap1p transcription factor [2].
  • A zrg17 mutant exhibits the same zinc-suppressible phenotypes as an msc2 mutant, including an induction of the unfolded protein response in low zinc [2].

Analytical, diagnostic and therapeutic context of ZRG17


  1. YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. Kumánovics, A., Poruk, K.E., Osborn, K.A., Ward, D.M., Kaplan, J. J. Biol. Chem. (2006) [Pubmed]
  2. Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells. Ellis, C.D., Macdiarmid, C.W., Eide, D.J. J. Biol. Chem. (2005) [Pubmed]
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