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Gene Review:

BRE5 - Bre5p

Saccharomyces cerevisiae S288c

Synonyms: Brefeldin-A sensitivity protein 5, N3465, UBP3-associated protein BRE5, YNR051C

Li, K. et al., Cohen, M. et al., Cohen, M. et al.

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High impact information on BRE5

Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23 [1].
Together, these studies provide novel insights into protein recognition by NTF2-like domains and provide a molecular scaffold for understanding how Ubp3 function is regulated by Bre5 cofactor binding [2].
In the present report, we show that disruption of BRE5 gene also led to a defect in the retrograde transport from the Golgi to the endoplasmic reticulum [3].

Other interactions of BRE5

Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor [2].
In this study, we report the x-ray crystal structure of the Bre5 NTF2-like domain and show that it forms a homodimeric structure that is similar to other NTF2-like domains, except for the presence of an intermolecular disulfide bond in the crystals [2].

References

Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Cohen, M., Stutz, F., Belgareh, N., Haguenauer-Tsapis, R., Dargemont, C. Nat. Cell Biol. (2003) [Pubmed]
Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor. Li, K., Zhao, K., Ossareh-Nazari, B., Da, G., Dargemont, C., Marmorstein, R. J. Biol. Chem. (2005) [Pubmed]
Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport. Cohen, M., Stutz, F., Dargemont, C. J. Biol. Chem. (2003) [Pubmed]

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