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Gene Review:

DSS4 - Dss4p

Saccharomyces cerevisiae S288c

Synonyms: LPZ16C, Protein DSS4, YP9531.11C, YPR017C

Collins, R.N. et al., Esters, H. et al.

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High impact information on DSS4

DSS4 overexpression can rescue the lethal phenotype of two alleles of SEC4, corresponding to dominant mutations of Ras [1].
We examined the relationship of GDI1 and DSS4 with SEC4 both genetically and biochemically [1].
Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins [2].

Anatomical context of DSS4

These results exclude a role for DSS4 in the recruitment of Sec4p/GDI onto membranes [1].

References

Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast. Collins, R.N., Brennwald, P., Garrett, M., Lauring, A., Novick, P. J. Biol. Chem. (1997) [Pubmed]
Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins. Esters, H., Alexandrov, K., Iakovenko, A., Ivanova, T., Thomä, N., Rybin, V., Zerial, M., Scheidig, A.J., Goody, R.S. J. Mol. Biol. (2001) [Pubmed]

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