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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RPC82  -  Rpc82p

Saccharomyces cerevisiae S288c

Synonyms: C74, C82, DNA-directed III 74 kDa polypeptide, DNA-directed RNA polymerase III subunit RPC3, P9677.11, ...
 
 
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Disease relevance of RPC82

  • These crosslinks occur at positions C74 and A76 in yeast tRNAMeti and position U64 in E. coli tRNATyr1&2 (conventional tRNA numbering system of Gauss & Sprinzl, 1981) [1].
 

High impact information on RPC82

  • An rpc82 temperature-sensitive mutant, constructed by in vitro mutagenesis of the gene, showed a deficient rate of tRNA relative to rRNA synthesis [2].
  • Four of the reactive cytidines are located in single-stranded regions: Cm32 , C60 , C74 and C75 . The five others are located in base pairs: C2, C27, C56 , C61 and C63 . Importance of replacement of an amino group by a thiol group on hydrogen bonding and on biological activity of the modified tRNA is discussed [3].

References

  1. Directly photocrosslinked nucleotides joining transfer RNA to aminoacyl-tRNA synthetase in methionine and tyrosine systems. Ackerman, E.J., Joachimiak, A., Klinghofer, V., Sigler, P.B. J. Mol. Biol. (1985) [Pubmed]
  2. RPC82 encodes the highly conserved, third-largest subunit of RNA polymerase C (III) from Saccharomyces cerevisiae. Chiannilkulchai, N., Stalder, R., Riva, M., Carles, C., Werner, M., Sentenac, A. Mol. Cell. Biol. (1992) [Pubmed]
  3. Chemical conversion of cytidine residues into 4-thiouridines in yeast tRNAPhe. Determination of the modified cytidines. Riehl, N., Carbon, P., Ehresmann, B., Ebel, J.P. Nucleic Acids Res. (1984) [Pubmed]
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