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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SSF1  -  Ssf1p

Saccharomyces cerevisiae S288c

Synonyms: Ribosome biogenesis protein SSF1, YHR066W
 
 
 
 
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High impact information on SSF1

  • Overexpression of SSF1 conferred the ability to form mating projections on cells containing a temperature-sensitive STE4 allele, but had only a small effect on transcriptional induction [1].
  • Cells containing null alleles of both SSF1 and SSF2 displayed the normal transcriptional induction response to pheromone but were unable to form mating projections [1].
  • SSF1 overexpression preferentially increased the mating efficiency of a strain containing a null allele of SPA2, a gene that functions specifically in cell morphology [1].
  • Overexpression of STE5, STE18 (which encodes the G gamma subunit), and a previously unidentified gene, termed SSF1, partially suppressed the mating defect of a G beta mutant [2].
 

Biological context of SSF1

  • Null mutations in either SSF1 or SSF2 had no obvious phenotype, but disruption of both genes was lethal [2].

References

  1. A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone. Kim, J., Hirsch, J.P. Genetics (1998) [Pubmed]
  2. An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. Yu, Y., Hirsch, J.P. DNA Cell Biol. (1995) [Pubmed]
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