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Gene Review

LAMTOR3  -  late endosomal/lysosomal adaptor, MAPK and...

Homo sapiens

Synonyms: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MAP2K1IP1, MAPBP, MAPKSP1, MEK-binding partner 1, ...
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Disease relevance of MAP2K1IP1

  • In a rat colon carcinoma model (DHD/K 12-PROb), two varieties of cells were selected after in vivo passaging: PROb h2, representing a liver-specific variant and PROb Mp1, representing a lung metastatic variant and producing liver and lung metastases after intracecal injection (one out of four) [1].


  1. Experimental model of liver metastases: adhesion and growth of cells on contact with endothelial or hepatocyte cell monolayer cultures. Bail, J.P., Foultier, M.T., Patrice, T. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1994) [Pubmed]
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