The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Neoplasm Metastasis

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neoplasm Metastasis


Psychiatry related information on Neoplasm Metastasis


High impact information on Neoplasm Metastasis


Chemical compound and disease context of Neoplasm Metastasis


Biological context of Neoplasm Metastasis


Anatomical context of Neoplasm Metastasis


Gene context of Neoplasm Metastasis

  • Visualization of gastrointestinal tumors and metastases was obtained with radiolabeled VIP [36].
  • The finding that Mi2beta exists in a complex containing histone deacetylase and nucleosome remodeling activities suggests a role for chromatin reorganization in cancer metastasis [37].
  • Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1 [16].
  • Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases [38].
  • Here we have determined the crystal structure of the DH and PH domains of the T-lymphoma invasion and metastasis factor 1 (Tiam1) protein in complex with its cognate Rho family G protein, Rac1 [39].
  • 1205Lu-Smad7 bone metastases expressed significantly lower levels of IL-11, connective tissue growth factor, and PTHrP [40].
  • Lung metastasis was abolished by infection with the antisense rAAV-CYP2J2 vector [41].
  • The combined analysis of N stage, vascular invasion, and RKIP expression is highly predictive of distant metastasis in patients with mismatch repair--proficient CRC [42].

Analytical, diagnostic and therapeutic context of Neoplasm Metastasis


  1. Reduction in new metastases in breast cancer with adjuvant clodronate treatment. Diel, I.J., Solomayer, E.F., Costa, S.D., Gollan, C., Goerner, R., Wallwiener, D., Kaufmann, M., Bastert, G. N. Engl. J. Med. (1998) [Pubmed]
  2. Treatment of brain metastases of malignant melanoma with temozolomide. Biasco, G., Pantaleo, M.A., Casadei, S. N. Engl. J. Med. (2001) [Pubmed]
  3. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. Kemeny, N., Huang, Y., Cohen, A.M., Shi, W., Conti, J.A., Brennan, M.F., Bertino, J.R., Turnbull, A.D., Sullivan, D., Stockman, J., Blumgart, L.H., Fong, Y. N. Engl. J. Med. (1999) [Pubmed]
  4. Activating SRC mutation in a subset of advanced human colon cancers. Irby, R.B., Mao, W., Coppola, D., Kang, J., Loubeau, J.M., Trudeau, W., Karl, R., Fujita, D.J., Jove, R., Yeatman, T.J. Nat. Genet. (1999) [Pubmed]
  5. Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer. Messing, E.M., Manola, J., Sarosdy, M., Wilding, G., Crawford, E.D., Trump, D. N. Engl. J. Med. (1999) [Pubmed]
  6. Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone. Yin, J., Pollock, C., Tracy, K., Chock, M., Martin, P., Oberst, M., Kelly, K. Mol. Cell. Biol. (2007) [Pubmed]
  7. Clinical relevance of cyclin D1 protein overexpression in laryngeal squamous cell carcinoma. Pignataro, L., Pruneri, G., Carboni, N., Capaccio, P., Cesana, B.M., Neri, A., Buffa, R. J. Clin. Oncol. (1998) [Pubmed]
  8. Nuclear 24 kD fibroblast growth factor (FGF)-2 confers metastatic properties on rat bladder carcinoma cells. Okada-Ban, M., Moens, G., Thiery, J.P., Jouanneau, J. Oncogene (1999) [Pubmed]
  9. Occurrence of sialic acids in healthy humans and different disorders. Sillanaukee, P., Pönniö, M., Jääskeläinen, I.P. Eur. J. Clin. Invest. (1999) [Pubmed]
  10. Combination therapy with vascular endothelial growth factor neutralizing antibody and mitomycin C on human gastric cancer xenograft. Matsumoto, K., Konno, H., Tanaka, T., Baba, M., Kanai, T., Kamiya, K., Ohba, K., Nakamura, S. Jpn. J. Cancer Res. (2000) [Pubmed]
  11. Visual hallucinations: a prevalence study among hospice inpatients. Fountain, A. Palliative medicine. (2001) [Pubmed]
  12. The biology of chemokines and their receptors. Rossi, D., Zlotnik, A. Annu. Rev. Immunol. (2000) [Pubmed]
  13. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Levy, S., Todd, S.C., Maecker, H.T. Annu. Rev. Immunol. (1998) [Pubmed]
  14. Role of the major histocompatibility complex class I antigens in tumor growth and metastasis. Tanaka, K., Yoshioka, T., Bieberich, C., Jay, G. Annu. Rev. Immunol. (1988) [Pubmed]
  15. Neurofibrosarcoma at irradiation site in a patient with neurofibromatosis and Wilms' tumor. Chu, J.Y., O'Connor, D.M., Danis, R.K. CA: a cancer journal for clinicians. (1981) [Pubmed]
  16. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Park, Y.G., Zhao, X., Lesueur, F., Lowy, D.R., Lancaster, M., Pharoah, P., Qian, X., Hunter, K.W. Nat. Genet. (2005) [Pubmed]
  17. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group. Hortobagyi, G.N., Theriault, R.L., Porter, L., Blayney, D., Lipton, A., Sinoff, C., Wheeler, H., Simeone, J.F., Seaman, J., Knight, R.D. N. Engl. J. Med. (1996) [Pubmed]
  18. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R.M., Nishimura, S., Imamura, Y., Kitayama, H., Alexander, D.B., Ide, C., Horan, T.P., Arakawa, T., Yoshida, H., Nishikawa, S., Itoh, Y., Seiki, M., Itohara, S., Takahashi, C., Noda, M. Cell (2001) [Pubmed]
  19. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Fan, Z., Beresford, P.J., Oh, D.Y., Zhang, D., Lieberman, J. Cell (2003) [Pubmed]
  20. Thromboxane synthase and organ preference for metastases. Nanji, A.A. N. Engl. J. Med. (1993) [Pubmed]
  21. Pancreatic cholera: benefical effects of treatment with streptozotocin. Kahn, C.R., Levy, A.G., Gardner, J.D., Miller, J.V., Gorden, P., Schein, P.S. N. Engl. J. Med. (1975) [Pubmed]
  22. Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases. Zhao, Y., Bachelier, R., Treilleux, I., Pujuguet, P., Peyruchaud, O., Baron, R., Clément-Lacroix, P., Clézardin, P. Cancer Res. (2007) [Pubmed]
  23. The cancer cell--leukocyte fusion theory of metastasis. Pawelek, J.M., Chakraborty, A.K. Adv. Cancer Res. (2008) [Pubmed]
  24. A Polymeric Nanoparticle Encapsulated Hedgehog Pathway Inhibitor HPI-1 (NanoHHI) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma. Xu, Y., Chenna, V., Hu, C., Sun, H.X., Khan, M., Bai, H., Yang, X.R., Zhu, Q.F., Sun, Y.F., Maitra, A., Fan, J., Anders, R.A. Clin. Cancer Res. (2011) [Pubmed]
  25. Elevated TNFR1 and serotonin in bone metastasis are correlated with poor survival following bone metastasis diagnosis for both carcinoma and sarcoma primary tumors. Chiechi, A., Novello, C., Magagnoli, G., Petricoin, E.F., Deng, J., Benassi, M.S., Picci, P., Vaisman, I., Espina, V., Liotta, L.A. Clin. Cancer Res. (2013) [Pubmed]
  26. The ubiquitin-CXCR4 axis plays an important role in acute lung infection-enhanced lung tumor metastasis. Yan, L., Cai, Q., Xu, Y. Clin. Cancer Res. (2013) [Pubmed]
  27. Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner. Palmieri, D., Duchnowska, R., Woditschka, S., Hua, E., Qian, Y., Biernat, W., Sosińska-Mielcarek, K., Gril, B., Stark, A.M., Hewitt, S.M., Liewehr, D.J., Steinberg, S.M., Jassem, J., Steeg, P.S. Clin. Cancer Res. (2014) [Pubmed]
  28. Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Hall, C.L., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L.A., Wang, C., Curpen, G.D., Savani, R.C., Greenberg, A.H., Turley, E.A. Cell (1995) [Pubmed]
  29. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang, J., Mani, S.A., Donaher, J.L., Ramaswamy, S., Itzykson, R.A., Come, C., Savagner, P., Gitelman, I., Richardson, A., Weinberg, R.A. Cell (2004) [Pubmed]
  30. Images in clinical medicine. Lung cancer presenting as an ankle metastasis. McGarry, R.C. N. Engl. J. Med. (2000) [Pubmed]
  31. DAP kinase links the control of apoptosis to metastasis. Inbal, B., Cohen, O., Polak-Charcon, S., Kopolovic, J., Vadai, E., Eisenbach, L., Kimchi, A. Nature (1997) [Pubmed]
  32. Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. Pipeleers-Marichal, M., Somers, G., Willems, G., Foulis, A., Imrie, C., Bishop, A.E., Polak, J.M., Häcki, W.H., Stamm, B., Heitz, P.U. N. Engl. J. Med. (1990) [Pubmed]
  33. Gene therapy of metastatic cancer by in vivo retroviral gene targeting. Hurford, R.K., Dranoff, G., Mulligan, R.C., Tepper, R.I. Nat. Genet. (1995) [Pubmed]
  34. Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo. Ossowski, L. Cell (1988) [Pubmed]
  35. Sunburn and p53 in the onset of skin cancer. Ziegler, A., Jonason, A.S., Leffell, D.J., Simon, J.A., Sharma, H.W., Kimmelman, J., Remington, L., Jacks, T., Brash, D.E. Nature (1994) [Pubmed]
  36. Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. Virgolini, I., Raderer, M., Kurtaran, A., Angelberger, P., Banyai, S., Yang, Q., Li, S., Banyai, M., Pidlich, J., Niederle, B., Scheithauer, W., Valent, P. N. Engl. J. Med. (1994) [Pubmed]
  37. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Zhang, Y., LeRoy, G., Seelig, H.P., Lane, W.S., Reinberg, D. Cell (1998) [Pubmed]
  38. Involvement of chemokine receptors in breast cancer metastasis. Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S.N., Barrera, J.L., Mohar, A., Verástegui, E., Zlotnik, A. Nature (2001) [Pubmed]
  39. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Worthylake, D.K., Rossman, K.L., Sondek, J. Nature (2000) [Pubmed]
  40. Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Javelaud, D., Mohammad, K.S., McKenna, C.R., Fournier, P., Luciani, F., Niewolna, M., André, J., Delmas, V., Larue, L., Guise, T.A., Mauviel, A. Cancer Res. (2007) [Pubmed]
  41. Cytochrome p450 epoxygenase promotes human cancer metastasis. Jiang, J.G., Ning, Y.G., Chen, C., Ma, D., Liu, Z.J., Yang, S., Zhou, J., Xiao, X., Zhang, X.A., Edin, M.L., Card, J.W., Wang, J., Zeldin, D.C., Wang, D.W. Cancer Res. (2007) [Pubmed]
  42. Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression. Zlobec, I., Baker, K., Minoo, P., Jass, J.R., Terracciano, L., Lugli, A. Clin. Cancer Res. (2008) [Pubmed]
  43. Natural history of progression after PSA elevation following radical prostatectomy. Pound, C.R., Partin, A.W., Eisenberger, M.A., Chan, D.W., Pearson, J.D., Walsh, P.C. JAMA (1999) [Pubmed]
  44. Carcinoembryonic antigen assay in hepatic metastases detection. An adjunct to liver scanning. McCartney, W.H., Hoffer, P.B. JAMA (1976) [Pubmed]
  45. Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis. Li, Y., Wang, M.N., Li, H., King, K.D., Bassi, R., Sun, H., Santiago, A., Hooper, A.T., Bohlen, P., Hicklin, D.J. J. Exp. Med. (2002) [Pubmed]
  46. Assessment of axillary lymph node involvement in breast cancer patients with positron emission tomography using radiolabeled 2-(fluorine-18)-fluoro-2-deoxy-D-glucose. Avril, N., Dose, J., Jänicke, F., Ziegler, S., Römer, W., Weber, W., Herz, M., Nathrath, W., Graeff, H., Schwaiger, M. J. Natl. Cancer Inst. (1996) [Pubmed]
WikiGenes - Universities