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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EIF3G  -  eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: EIF3-P42, EIF3S4, Eukaryotic translation initiation factor 3 RNA-binding subunit, Eukaryotic translation initiation factor 3 subunit 4, Eukaryotic translation initiation factor 3 subunit G, ...
 
 
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High impact information on EIF3S4

  • Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus [1].
  • Here we report the cloning and characterization of human cDNAs encoding two more subunits of human eIF3, namely eIF3-p44 and eIF3-p35 [2].
  • Northwestern blotting shows that eIF3-p44 binds 18 S rRNA and beta-globin mRNA [2].
 

Other interactions of EIF3S4

  • The essential sequence for this interaction was mapped to the carboxyl-terminus of 4.1R (residues 525-622) and a region (residues 54-321) of eIF3-p44 [1].
 

Analytical, diagnostic and therapeutic context of EIF3S4

References

  1. Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus. Hou, C.L., Tang, C., Roffler, S.R., Tang, T.K. Blood (2000) [Pubmed]
  2. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. Block, K.L., Vornlocher, H.P., Hershey, J.W. J. Biol. Chem. (1998) [Pubmed]
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