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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ORF1  -  hypothetical protein 1

Chlamydia psittaci

 
 
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Disease relevance of ORF1

  • Both ORF1 and ORF2 are required for the appearance of chlamydia-specific LPS on the surface of recombinant E. coli [1].
 

High impact information on ORF1

  • These findings are in agreement with the hypothesis that the ORF1-encoded protein is involved in, but not essential for, plasmid replication and control of copy number [2].
  • C. pneumoniae strain N16 supports a 7.4 kbp plasmid in which ORF1, encoding one of the putative Rep proteins, is disrupted by a deletion and split into two smaller ORFs [2].
 

Biological context of ORF1

  • The disruption of ORF 1 is the only significant variation identified amongst the chlamydial plasmids and could prove important for future vector development studies [3].
  • The reduced size of this plasmid was due to a single large deletion occurring within ORF 1; this potentially generates two smaller ORFs [3].

References

  1. Lipopolysaccharide biosynthesis genes in koala type I Chlamydia: cloning and characterization. Girjes, A.A., Carrick, F.N., Lavin, M.F. Res. Microbiol. (1997) [Pubmed]
  2. The plasmids of Chlamydia trachomatis and Chlamydophila pneumoniae (N16): accurate determination of copy number and the paradoxical effect of plasmid-curing agents. Pickett, M.A., Everson, J.S., Pead, P.J., Clarke, I.N. Microbiology (Reading, Engl.) (2005) [Pubmed]
  3. Plasmid diversity in Chlamydia. Thomas, N.S., Lusher, M., Storey, C.C., Clarke, I.N. Microbiology (Reading, Engl.) (1997) [Pubmed]
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