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Gene Review

exoY  -  adenylate cyclase

Pseudomonas aeruginosa PAO1

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Disease relevance of exoY


High impact information on exoY

  • Therefore, we have systematically deleted the genes for the three known type III effector molecules (exoS, exoT, and exoY) in P. aeruginosa PAO1 and assayed the effect of the deletions, both singly and in combination, on cytotoxicity in vitro and in vivo [2].
  • In contrast, the exoS, exoU and exoY genes were variable traits [3].


  1. Single-nucleotide-polymorphism mapping of the Pseudomonas aeruginosa type III secretion toxins for development of a diagnostic multiplex PCR system. Ajayi, T., Allmond, L.R., Sawa, T., Wiener-Kronish, J.P. J. Clin. Microbiol. (2003) [Pubmed]
  2. Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo. Vance, R.E., Rietsch, A., Mekalanos, J.J. Infect. Immun. (2005) [Pubmed]
  3. Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Feltman, H., Schulert, G., Khan, S., Jain, M., Peterson, L., Hauser, A.R. Microbiology (Reading, Engl.) (2001) [Pubmed]
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