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Gene Review:

exoY - adenylate cyclase

Pseudomonas aeruginosa PAO1

Vance, R.E. et al., Ajayi, T. et al., Feltman, H. et al.

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Disease relevance of exoY

We mapped the coding single nucleotide polymorphisms in four toxin genes-exoS, exoT, exoU, and exoY-of the Pseudomonas aeruginosa type III secretion system among several clinical isolates [1].

High impact information on exoY

Therefore, we have systematically deleted the genes for the three known type III effector molecules (exoS, exoT, and exoY) in P. aeruginosa PAO1 and assayed the effect of the deletions, both singly and in combination, on cytotoxicity in vitro and in vivo [2].
In contrast, the exoS, exoU and exoY genes were variable traits [3].

References

Single-nucleotide-polymorphism mapping of the Pseudomonas aeruginosa type III secretion toxins for development of a diagnostic multiplex PCR system. Ajayi, T., Allmond, L.R., Sawa, T., Wiener-Kronish, J.P. J. Clin. Microbiol. (2003) [Pubmed]
Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo. Vance, R.E., Rietsch, A., Mekalanos, J.J. Infect. Immun. (2005) [Pubmed]
Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Feltman, H., Schulert, G., Khan, S., Jain, M., Peterson, L., Hauser, A.R. Microbiology (Reading, Engl.) (2001) [Pubmed]

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