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Gene Review:

espK - ESX-1 secretion-associated protein EspK

Mycobacterium tuberculosis H37Rv

Liu, X.Q. et al., Inwald, J. et al.

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Disease relevance of Rv3879c

We investigated four novel gene products, encoded by RD2 (Rv1989c) and RD1 (Rv3873, Rv3878, and Rv3879c), that are absent from most or all of the vaccine strains of BCG, respectively [1].

High impact information on Rv3879c

Forty-five percent (95% confidence interval [CI], 31 to 57%) and 53% (95% CI, 39 to 67%) of the tuberculosis patients responded to Rv3879c and Rv3873, respectively, identifying these proteins as major M. tuberculosis T-cell antigens in humans, while 35 and 25% of the patients responded to Rv3878 and Rv1989c, respectively [1].
The RD1 gene Rv3879c encodes a proline- and alanine-rich protein that shows sequence polymorphism across members of the M. tuberculosis complex [2].

References

Evaluation of T-cell responses to novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection. Liu, X.Q., Dosanjh, D., Varia, H., Ewer, K., Cockle, P., Pasvol, G., Lalvani, A. Infect. Immun. (2004) [Pubmed]
Inactivation of the Mycobacterium bovis homologue of the polymorphic RD1 gene Rv3879c (Mb3909c) does not affect virulence. Inwald, J., Jahans, K., Hewinson, R.G., Gordon, S.V. Tuberculosis (Edinburgh, Scotland) (2003) [Pubmed]

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