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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TOP3B  -  topoisomerase (DNA) III beta

Homo sapiens

Synonyms: DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B1
 
 
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High impact information on TOP3B

  • The TOP3B gene encodes a protein that seems to function in the unlinking of parental strands at the final stage of DNA replication and/or in the dissociation of structures in mitotic cells that could lead to recombination [1].
  • Analysis of these two amplified regions revealed the presence of two interesting candidate genes: TOP3B and TAFA5 [1].

References

  1. Chromosome 22 tiling-path array-CGH analysis identifies germ-line- and tumor-specific aberrations in patients with glioblastoma multiforme. de Ståhl, T.D., Hartmann, C., de Bustos, C., Piotrowski, A., Benetkiewicz, M., Mantripragada, K.K., Tykwinski, T., von Deimling, A., Dumanski, J.P. Genes Chromosomes Cancer (2005) [Pubmed]
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