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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IDI2  -  isopentenyl-diphosphate delta isomerase 2

Homo sapiens

Synonyms: IPP isomerase 2, IPPI2, Isopentenyl pyrophosphate isomerase 2, Isopentenyl-diphosphate delta-isomerase 2
 
 
 
 
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High impact information on IDI2

  • Molecular modeling shows that the modified IDI2 is still likely to catalyze the isomerization of IPP to DMAPP [1].
  • The significant positive fitness effect of IDI2, revealed by the pattern of sequence conservation, as well as its specific expression pattern underscores the importance of the IDI gene duplication in mammals [1].
  • In humans, IDI2 is expressed at high levels only in skeletal muscle, where it may be involved in the specialized production of isoprenyl diphosphates for the posttranslational modification of proteins [1].

References

  1. Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. Breitling, R., Laubner, D., Clizbe, D., Adamski, J., Krisans, S.K. J. Mol. Evol. (2003) [Pubmed]
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