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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Duplication

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Disease relevance of Gene Duplication


Psychiatry related information on Gene Duplication

  • CONCLUSION: These results suggest that the CYP2D6 gene duplication is a possible factor that influences the development of persistence in patients with mood disorders probably by ultrarapid drug metabolism [6].

High impact information on Gene Duplication


Chemical compound and disease context of Gene Duplication


Biological context of Gene Duplication


Anatomical context of Gene Duplication


Associations of Gene Duplication with chemical compounds

  • Interestingly, NUP100 and NUP116 are both flanked by a histidine tRNA gene and a transposon element suggesting that they may have arisen by gene duplication [23].
  • Structure and expression of AtAurora1 and AtAurora2 suggest that these genes arose by a recent gene duplication, whereas the diversification of plant alpha and beta Aurora kinases predates the origin of land plants [24].
  • It is suggested that the mouse C4 gene duplication is an evolutionarily recent event with respect to the time of mammalian radiation [25].
  • It was also found that the number of arginine residues increased substantially in a short period of evolutionary time after gene duplication, and these amino acid changes probably produced the novel anti-pathogen function of ECP [26].
  • The determined sequence of the alpha chain of glycoprotein Ib contains a region (residues 29-193) with seven repeats, which is indicative of gene duplication and is highly homologous to human leucine-rich alpha 2-glycoprotein [27].

Gene context of Gene Duplication

  • These data suggest that LHR, ELAM-1, and GMP-140 comprise an adhesion protein family, the selectins, that arose by multiple gene duplication events before divergence of mouse and human [28].
  • Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase [29].
  • Saccharomyces cerevisiae cells are exquisitely sensitive to altered dosage of the spindle pole body duplication gene, NDC1 [30].
  • Multiple paralogons surrounding the CHC genes (CLTC and CLTD) were identified, evidence that genomic or large-scale gene duplication produced the two CHC isoforms [31].
  • In contrast, clathrin light chain genes (CLTA and CLTB) apparently arose by localized duplication, within 1-11 million years of CHC gene duplication [31].

Analytical, diagnostic and therapeutic context of Gene Duplication


  1. Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome. Delabar, J.M., Goldgaber, D., Lamour, Y., Nicole, A., Huret, J.L., de Grouchy, J., Brown, P., Gajdusek, D.C., Sinet, P.M. Science (1987) [Pubmed]
  2. The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture. Merckel, M.C., Huiskonen, J.T., Bamford, D.H., Goldman, A., Tuma, R. Mol. Cell (2005) [Pubmed]
  3. Gene duplication and speciation in Drosophila: evidence from the Odysseus locus. Ting, C.T., Tsaur, S.C., Sun, S., Browne, W.E., Chen, Y.C., Patel, N.H., Wu, C.I. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I. Ciullo, M., Debily, M.A., Rozier, L., Autiero, M., Billault, A., Mayau, V., El Marhomy, S., Guardiola, J., Bernheim, A., Coullin, P., Piatier-Tonneau, D., Debatisse, M. Hum. Mol. Genet. (2002) [Pubmed]
  5. Human retroviral sequences on the Y chromosome. Silver, J., Rabson, A., Bryan, T., Willey, R., Martin, M.A. Mol. Cell. Biol. (1987) [Pubmed]
  6. Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study. Kawanishi, C., Lundgren, S., Agren, H., Bertilsson, L. Eur. J. Clin. Pharmacol. (2004) [Pubmed]
  7. Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes. Hoffmann, F.M., Fresco, L.D., Hoffman-Falk, H., Shilo, B.Z. Cell (1983) [Pubmed]
  8. Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Young, L.J., Nilsen, R., Waymire, K.G., MacGregor, G.R., Insel, T.R. Nature (1999) [Pubmed]
  9. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Lifton, R.P., Dluhy, R.G., Powers, M., Rich, G.M., Cook, S., Ulick, S., Lalouel, J.M. Nature (1992) [Pubmed]
  10. The seal myoglobin gene: an unusually long globin gene. Blanchetot, A., Wilson, V., Wood, D., Jeffreys, A.J. Nature (1983) [Pubmed]
  11. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. Tanzi, R.E., Bird, E.D., Latt, S.A., Neve, R.L. Science (1987) [Pubmed]
  12. Dihydrolipoamide transacetylase from Escherichia Coli: evidence for internal gene duplication. Gebhardt, C., Mecke, D., Bisswanger, H. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
  13. Structure of the human interleukin-2 receptor gene. Leonard, W.J., Depper, J.M., Kanehisa, M., Krönke, M., Peffer, N.J., Svetlik, P.B., Sullivan, M., Greene, W.C. Science (1985) [Pubmed]
  14. Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Ben-David, Y., Giddens, E.B., Letwin, K., Bernstein, A. Genes Dev. (1991) [Pubmed]
  15. Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expression. Tilley, S.A., Birshtein, B.K. J. Exp. Med. (1985) [Pubmed]
  16. VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules. Hartman, A.B., Rudikoff, S. EMBO J. (1984) [Pubmed]
  17. Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein. Golden, B.L., Ramakrishnan, V., White, S.W. EMBO J. (1993) [Pubmed]
  18. The evolution of morphological complexity in zebrafish stripes. Mellgren, E.M., Johnson, S.L. Trends Genet. (2002) [Pubmed]
  19. cDNA sequence encoding the 16-kDa proteolipid of chromaffin granules implies gene duplication in the evolution of H+-ATPases. Mandel, M., Moriyama, Y., Hulmes, J.D., Pan, Y.C., Nelson, H., Nelson, N. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  20. Genetic basis for the evolution of vertebrate mineralized tissue. Kawasaki, K., Suzuki, T., Weiss, K.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  21. Lamprey Dlx genes and early vertebrate evolution. Neidert, A.H., Virupannavar, V., Hooker, G.W., Langeland, J.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  22. A transferrinlike (hemiferrin) mRNA is expressed in the germ cells of rat testis. Stallard, B.J., Collard, M.W., Griswold, M.D. Mol. Cell. Biol. (1991) [Pubmed]
  23. A new family of yeast nuclear pore complex proteins. Wente, S.R., Rout, M.P., Blobel, G. J. Cell Biol. (1992) [Pubmed]
  24. Identification and dynamics of two classes of aurora-like kinases in Arabidopsis and other plants. Demidov, D., Van Damme, D., Geelen, D., Blattner, F.R., Houben, A. Plant Cell (2005) [Pubmed]
  25. Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp. Levi-Strauss, M., Tosi, M., Steinmetz, M., Klein, J., Meo, T. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  26. Positive Darwinian selection after gene duplication in primate ribonuclease genes. Zhang, J., Rosenberg, H.F., Nei, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Titani, K., Takio, K., Handa, M., Ruggeri, Z.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. Watson, M.L., Kingsmore, S.F., Johnston, G.I., Siegelman, M.H., Le Beau, M.M., Lemons, R.S., Bora, N.S., Howard, T.A., Weissman, I.L., McEver, R.P. J. Exp. Med. (1990) [Pubmed]
  29. Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. Lauzé, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R., Winey, M. EMBO J. (1995) [Pubmed]
  30. Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Chial, H.J., Giddings, T.H., Siewert, E.A., Hoyt, M.A., Winey, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P., Brodsky, F.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  32. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Sachse, C., Brockmöller, J., Bauer, S., Roots, I. Am. J. Hum. Genet. (1997) [Pubmed]
  33. Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication. Boel, E., Vuust, J., Norris, F., Norris, K., Wind, A., Rehfeld, J.F., Marcker, K.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  34. Functional organization of mammalian hexokinase II. Retention of catalytic and regulatory functions in both the NH2- and COOH-terminal halves. Ardehali, H., Yano, Y., Printz, R.L., Koch, S., Whitesell, R.R., May, J.M., Granner, D.K. J. Biol. Chem. (1996) [Pubmed]
  35. Duplication of the proteolipid protein gene is the major cause of Pelizaeus-Merzbacher disease. Sistermans, E.A., de Coo, R.F., De Wijs, I.J., Van Oost, B.A. Neurology (1998) [Pubmed]
  36. The primate psi beta 1 gene. An ancient beta-globin pseudogene. Harris, S., Barrie, P.A., Weiss, M.L., Jeffreys, A.J. J. Mol. Biol. (1984) [Pubmed]
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