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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Gene Duplication

 
 
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Disease relevance of Gene Duplication

 

Psychiatry related information on Gene Duplication

  • CONCLUSION: These results suggest that the CYP2D6 gene duplication is a possible factor that influences the development of persistence in patients with mood disorders probably by ultrarapid drug metabolism [6].
 

High impact information on Gene Duplication

 

Chemical compound and disease context of Gene Duplication

 

Biological context of Gene Duplication

 

Anatomical context of Gene Duplication

 

Associations of Gene Duplication with chemical compounds

  • Interestingly, NUP100 and NUP116 are both flanked by a histidine tRNA gene and a transposon element suggesting that they may have arisen by gene duplication [23].
  • Structure and expression of AtAurora1 and AtAurora2 suggest that these genes arose by a recent gene duplication, whereas the diversification of plant alpha and beta Aurora kinases predates the origin of land plants [24].
  • It is suggested that the mouse C4 gene duplication is an evolutionarily recent event with respect to the time of mammalian radiation [25].
  • It was also found that the number of arginine residues increased substantially in a short period of evolutionary time after gene duplication, and these amino acid changes probably produced the novel anti-pathogen function of ECP [26].
  • The determined sequence of the alpha chain of glycoprotein Ib contains a region (residues 29-193) with seven repeats, which is indicative of gene duplication and is highly homologous to human leucine-rich alpha 2-glycoprotein [27].
 

Gene context of Gene Duplication

  • These data suggest that LHR, ELAM-1, and GMP-140 comprise an adhesion protein family, the selectins, that arose by multiple gene duplication events before divergence of mouse and human [28].
  • Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase [29].
  • Saccharomyces cerevisiae cells are exquisitely sensitive to altered dosage of the spindle pole body duplication gene, NDC1 [30].
  • Multiple paralogons surrounding the CHC genes (CLTC and CLTD) were identified, evidence that genomic or large-scale gene duplication produced the two CHC isoforms [31].
  • In contrast, clathrin light chain genes (CLTA and CLTB) apparently arose by localized duplication, within 1-11 million years of CHC gene duplication [31].
 

Analytical, diagnostic and therapeutic context of Gene Duplication

References

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  23. A new family of yeast nuclear pore complex proteins. Wente, S.R., Rout, M.P., Blobel, G. J. Cell Biol. (1992) [Pubmed]
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  25. Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp. Levi-Strauss, M., Tosi, M., Steinmetz, M., Klein, J., Meo, T. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
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  28. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. Watson, M.L., Kingsmore, S.F., Johnston, G.I., Siegelman, M.H., Le Beau, M.M., Lemons, R.S., Bora, N.S., Howard, T.A., Weissman, I.L., McEver, R.P. J. Exp. Med. (1990) [Pubmed]
  29. Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. Lauzé, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R., Winey, M. EMBO J. (1995) [Pubmed]
  30. Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. Chial, H.J., Giddings, T.H., Siewert, E.A., Hoyt, M.A., Winey, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P., Brodsky, F.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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