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Gene Review

ihfB  -  integration host factor subunit beta

Escherichia coli O157:H7 str. Sakai

 
 
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Disease relevance of ECs0995

  • We describe the isolation and sequencing of the hip gene of Escherichia coli and show that it encodes the beta subunit of integration host factor (IHF beta) [1].
  • The ihf genes (ihfA and ihfB) were cloned from N. gonorrhoeae through functional complementation of defined Escherichia coli ihf mutants for plating of phage lambda [2].
  • The ihfA and ihfB genes encode polypeptides predicted to be 99 and 93 amino acids long, respectively, and are very similar to integration host factor subunits from other Gram-negative bacteria, although phylogenetic analysis indicated that the P. haemolytica sequences are distantly related to those from other bacteria [3].
 

High impact information on ECs0995

  • We found a probable promoter for hip located about 85 base-pairs upstream from the initial AUG codon and about 75 base-pairs downstream from the 3' end of the neighboring gene, rpsA, and we constructed an IHF beta overproducer by fusing the coding sequences to the lambda pL promoter [1].
  • In attempts to identify subunit-specific phenotypes of ihf mutants we analyzed viability, thermoresistance and protein synthesis patterns in ihfA and ihfB mutants and their respective parental strains [4].

References

  1. Primary structure of the hip gene of Escherichia coli and of its product, the beta subunit of integration host factor. Flamm, E.L., Weisberg, R.A. J. Mol. Biol. (1985) [Pubmed]
  2. The ihf mRNA levels decline as Neisseria gonorrhoeae enters the stationary growth phase. Hill, S.A., Belland, R.J., Wilson, J. Gene (1998) [Pubmed]
  3. Isolation and characterization of the integration host factor genes of Pasteurella haemolytica. Highlander, S.K., Garza, O., Brown, B.J., Koby, S., Oppenheim, A.B. FEMS Microbiol. Lett. (1997) [Pubmed]
  4. Selected phenotypes of ihf mutants of Escherichia coli. Bykowski, T., Sirko, A. Biochimie (1998) [Pubmed]
 
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