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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

aga  -  alpha-galactosidase

Streptococcus pneumoniae R6

 
 
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High impact information on aga

  • The aga promoter P(A) is negatively regulated by the presence of sucrose in the growth medium [1].
  • Consistent with catabolite repression (CR), a DNA sequence with high homology to the CRE (cis-active element) was identified upstream of the aga promoter [1].
  • However, an unknown ComE-dependent regulator is also required for competence when comX is expressed under control of the raffinose-responsive promoter of the aga operon [2].

References

  1. Regulation of the alpha-galactosidase activity in Streptococcus pneumoniae: characterization of the raffinose utilization system. Rosenow, C., Maniar, M., Trias, J. Genome Res. (1999) [Pubmed]
  2. Identification of ComW as a new component in the regulation of genetic transformation in Streptococcus pneumoniae. Luo, P., Li, H., Morrison, D.A. Mol. Microbiol. (2004) [Pubmed]
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