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Gene Review:

ORF1 - putative replicase

Grapevine virus B

Minafra, A. et al., Saldarelli, P. et al.

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Disease relevance of ORF1

ORF 1 coded for a 194.7 kDa polypeptide with conserved motifs of replication-related proteins of positive-strand RNA viruses (i.e. methyltransferase, helicase and RNA-dependent RNA polymerase, in that order from the N to the C terminus) [1].

High impact information on ORF1

Two putative open reading frames (ORF) were identified: ORF 1 that codes for a 194 kDa polypeptide with conserved motifs of replication-related proteins of positive-strand RNA viruses, and ORF 2 that encodes a 19 kDa polypeptide with no significant homology with protein sequences from databases [2].

References

The nucleotide sequence and genomic organization of grapevine virus B. Saldarelli, P., Minafra, A., Martelli, G.P. J. Gen. Virol. (1996) [Pubmed]
Grapevine virus A: nucleotide sequence, genome organization, and relationship in the Trichovirus genus. Minafra, A., Saldarelli, P., Martelli, G.P. Arch. Virol. (1997) [Pubmed]

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